The Study Of Chinese Medicine Patterns And Treatments Of Gout Arthritis Based On Clustering Analysis

ObjectiveThis thesis analyzed pattern distribution and remedy regularity in clinical trials of Chinese Medicine treating gout during last 15 years, aiming to summarize Chinese Medicine patterns and treatments of gout in different stages, to provide valuable reference to Chinese Medicine clinical practice treating gout.MethodThe author search CNKI using query [(SU=’痛风性关节炎’) and (SU=’中西 医结合疗法’or SU=’中医疗法’ or SU=’中药疗法’)] from 2000-1-1 to 2014-12-31 in advanced search, coming out with 193 articles. According to the inclusive criteria and exclusive criteria,106 articles were selected at last. Data base was established with Excel. SPSS 12.0 and Excel were used for statistics and cluster analysis.ResultsIn all 106 articles included, there was 96 of acute gout arthritis,8 of chronic gout arthritis, and 2 of both acute and chronic gout arthritis. There were 12 pattern elements in total. All 12 pattern elements including Shi, Yu, Zhuo, Du etc. involved in acute gout arthritis.7 pattern elements including Shi, Yu, Qixu, Zhuo etc. involved in chronic gout arthritis. Among all there was 136 patterns in total, in which 112 of acute gout arthritis,13 of chronic gout arthritis. Major patterns of acute gout arthritis were ShiReZuLuo, PiShenLiangXu, ShiReZuZhi. Major Patterns of chronic gout arthritis were Tanshizuluo, Pishenliangxu.110 formulas were reported, forming by 153 different herbs (mentioned 1364 times), which could divide into 17 categories, or 35 lesser categories. Most used herbs were those of categories of LiShuiShenShi, BuQi, QuFengShi. In acute phase, herbs with the efficacy of QingRe, LiShuiShenShi, HuoXueHuaYu, such as YiYiRen, ChuanNiuXi, HuangBo, TuFuLing, ChangZhu, FenBiXie were frequently used. In chronic phase, herbs with the efficacy of BuXu, HuoXueHuaYu, LiShuiShenShi, QingRe, such as ChuanNiuXi, BaiZhu, FenBiXie, HuangQi, TuFuLing were frequently used.ConclusionAccording to analyzing the literature of Gout in the past 15 years, opinions of patterns and treatment to gout remained controversial, but understandings of its etiology and pathogenesis were similar. It was mainly focus on spleen and kidney deficiency, exopathogen. Symptoms and severity depends on the balance of Zheng and Xie. Dampness, embolism were the main pathogens. The most common deficiency were Qi-deficiency and Yang-deficiency, involving the ZangFu of spleen and kidney. From the Age of the Inner Canon of Huangdi, physicians tried to summarize the clinical feature, etiology and pathogenesis of gout, theories were made and therapies were practiced, lately different therapy were used to treat patients in different phrases. This thesis used data mining on literatures of Chinese Medicine clinical trials in the new centuries, following keys were concluded:In acute phase, herbs with the efficacy of QingRe, LiShuiShenShi, HuoXueHuaYu, BuXu should be considered. In chronic phase, herbs with the efficacy of BuXu, HuoXueHuaYu, LiShuiShenShi, QingRe should be considered. In clinical practice, optimal treatment of specific patterns should be individualized case by case.