Study Of Treating Liver Damage With Soothing Liver And Invigorating Spleen

PurposeLiver injury is a clinical common diseases endangering human health, it is common to the various liver disease a pathological physiological process, the early prevention, can prevent liver fibrosis, cirrhosis and even liver cancer. But with the development of modern medicine, the current in the pathogenesis of liver injury has a lot of research, the treatment also had a deeper understanding, It found that many Chinese medicine and its preparation has its uniqueness and superiority. The liver and spleen on physiological pathology are closely related. This topic through the experimental research method of the spleen, liver and spleen and Soothing Liver and Invigorating Spleen three methods of ConA induced immunological liver injury caused by impact, compare the three methods of ConA immune liver injury in mice caused by the curative effect of protection, to train of thought and the theoretical foundation for clinical treatment of liver injury.MethodsBy establishing the sword bean globulin A immune liver injury in mice model, using the research methods such as biochemical detection, molecular biology research sijunzi decoction, four inverse scattering, sijunzi decoction, and four inverse scattering and the influence on immunological liver injury in mice liver function damage mechanism, and then discusses comparative liver, spleen and Soothing Liver and Invigorating Spleen on ConA induced immunological liver injury in mice spleen method the curative effect of protection.Results1.The method of soothing the liver, the spleen method group, Soothing Liver and Invigorating Spleen and ALT, AST level method group were less than model group, compared with statistical significance (P< 0.05), liver and spleen method has no statistical significance between groups, and Soothing Liver and Invigorating Spleen and liver group, the Soothing Liver and Invigorating Spleen and spleen method between groups were statistically significant (P< 0.05), and Soothing Liver and Invigorating Spleen and liver tissue of mice ALT, AST levels were lower than that of liver and spleen method group.2.Method of soothing the liver, the spleen method group, Soothing Liver and Invigorating Spleen to set the level of MDA was lower than the model group, the comparison were statistically significant (P< 0.05); Method of soothing the liver, the spleen method group, Soothing Liver andInvigorating Spleen and no statistical difference between groups.3.Method of soothing the liver, the spleen method group, Soothing Liver and Invigorating Spleen tissue of mice method of gsh-px levels were higher than that of model group, contrast were statistically significant (P< 0.05); Liver and spleen method no statistical difference between groups, and Soothing Liver and Invigorating Spleen and liver group, Soothing Liver and Invigorating Spleen and spleen between groups were statistically significant differences (P< 0.05), and Soothing Liver and Invigorating Spleen of mice liver gsh-px levels were higher than that of liver and spleen method group.4.Method of soothing the liver, the spleen method group, Soothing Liver and Invigorating Spleen tissue of mice method of the level of SOD was higher than that of model group, liver method VS model group P= 0.215,, spleen method VS model group P= 0.375, Soothing Liver and Invigorating Spleen method VS model group P< 0.01. Prompt Soothing Liver and Invigorating Spleen and there are statistically significant differences between model group (P< 0.01). Liver and spleen method no statistical difference between groups, and Soothing Liver and Invigorating Spleen and liver between groups was statistically difference (P< 0.05), Soothing Liver and Invigorating Spleen and spleen method between groups had statistically significant difference (P< 0.01), and Soothing Liver and Invigorating Spleen of mice liver tissue SOD levels were higher than that of liver and spleen method group.Conclusion1.Sword bean protein A (ConA) to immune liver injury in mice model is effective.2.Smoothhing liver, reinforcing spleen, soothing Liver and invigorating Spleen can effectively reduce the AST and ALT activity, inhibiting liver injury in mice liver tissue MDA content and increase gsh-px in damage to the liver, the content of SOD, but Soothing Liver and Invigorating Spleen method compared to the single liver or spleen method curative effect is better. The treatment of the Soothing Liver and Invigorating Spleen has its rationality and validity.