Atorvastatin Improve The Endothelial Function By Influenc The Levels Of Homocysteine In Patients With H-Type Hypertension Disease

Objective:To investigate the influence of different doses of atorvastatin on homocysteine, endothelial function and c-reactive protein in patients with H-type hypertension. And analyze whether atorvastatin can improve the endothelial function by influenc the levels of homocysteine in patients with H-type hypertension disease.Methods:By gathering 120 cases of H-type hypertension patients that cured in the retired veteran cadres ward,cardiology and outpatient in December 2013-June 2015. 120 patients with H-type hypertension were divided into three groups randomly: the control group, the conventional treatment group and the intensive treatment group(40 cases in each group). Control group using conventional antihypertensive therapy(beta receptor blockers,ACEI, ARB, calcium channel blockers, diuretics, etc.); the conventional treatment group is respectively treated with 20 mg atorvastatin on the basis of routine treatment;and intensive treatment group is respectively treated with 40 mg atorvastatin on the basis of routine treatment. Serum homocysteine, endothelin, nitric oxide, c-reactive protein contents were measured before the start of the experiment and after 12 weeks therapy.All the blood samples were collected in the early morning on an empty stomach. Avoid drinking alcohol and eating high-fat diet, don’t do strenuous exercise before the blood samples. Triglyceride(TG), cholesterol(TC), low density lipoprotein cholesterol(LDL- C) and high-density lipoprotein cholesterol(HDL- C) adopt oxide enzymatic detection, by our hospital clinical laboratory automatic biochemical analyzer(Hitachi 7170 s) once testing is complete. ET-1 determination by ria method, NO determination of nitrate reduction method, CRP determination by immunofluorescence dry quantitative method, Hcy using circulating enzymatic.Results:The levels of homocysteine, endothelin, nitric oxide, and c-reactive protein were all statistically significant(P < 0.05) in both conventional treatment group and intensive treatment group before and after therapy. The index of homocysteine, endothelin, nitric oxide and c-reactive protein after treatment in both the conventional treatment group and intensive treatment group were all significantly different from those in the control group(P < 0.05). The levels of homocysteine, endothelin, nitric oxide and c-reactive protein after treatment in the intensive treatment group all showed significant differences with those in the conventional treatment group. Intensive treatment group and routine treatment group Hcy descent level and ET-1 descent level were positively correlated(P < 0.05). Intensive treatment group and conventional treatment group Hcy descent levels and negatively correlated with NO rising levels(P < 0.05).Conclusions:1. Atorvastatin can decrease the levels of homocysteine and improve endothelial function in patients with H-type hypertension.High-dose of atorvastatin can more effectively reduce homocysteine levels,improve endothelial function, inhibit inflammation in patients with H-type hypertension than regular of atorvastatin,thus improving the effect of treatment as well. And atorvastatin can improve the endothelial function, consideration may be associated with lower serum homocysteine levels in patients with H-type hypertension disease.