HRCT Features And Pathologic Basis Of Pulmonary Ground Glass Opacity Less Than 2cm

Objective To investigate the relationship between HRCT features and pathological classification of pulmonary ground glass opacity(GGO) less than 2 cm.Materials and methods A retrospective analysis from January 2012 to December 2015, pulmonary ground glass opacities less than 2 cm were selected from 137 people, a total of 152 lesions. There were 56 males and 96 females, the age range 20~80 years with average age 53.3±12.9 years, the size of the lesions ranged from 4.9~20.0mm, with an average size of 15.13±4.18 mm. The lesions were surgery after resection of pathologically confirmed. The image analysis includes: lesion location, lesion size and lesion size and density, solid density, solid density, size and proportion of the lesion edge(lobulation, short burr, long thorn), internal lesions(vacuole sign, air bronchogram), pleural indentation sign, vascular lesions and the relationship between. The single factor analysis of variance(One-Way ANOVA) to analyze the differences between the size, density and different pathological classification of the lesion and solid component, P<0.05 showed a statistically significant difference; using chi square test or Fisher exact test of gender, lesion distribution, lesion edge, and pleural retraction the same with the pathological classification difference analysis; using the difference between the rank and inspection of the lesion and pulmonary vessels with pathological classification analysis. The infiltration of inflammatory lesions and adenocarcinoma lesions, precancerous lesions and invasive lesions and solid size, density, size and density of the proportion of the use of ROC curve.Results Gender, age, location of lesions in different pathological types had no significant difference, the difference was statistically significant in different pathological lesions group size(P<0.001), The tumor size of infiltration group(MIA+IAC) was larger than the before the infiltration group(AAH+AIS), the before the infiltration group(AAH+AIS) was larger than the inflammatory disease group(INF). Different pathological group occurrence rate had significant difference, AIS, MIA and IAC compared with group INF and AAH group ar more likely to appear solid component, solid component size, infiltrating lesions group(MIA+IAC) than the preinvasive lesion group(AAH+AIS) more. Different pathological lesion density, solid density had significant difference,The lesion density of IAC and MIA was highest in all groups, The group of INF and AAH were the lowest density. the highest density of solid was INF or IAC,. The ROC curve of inflammatory lesions group and adenocarcinoma lesions group showed the lesion size, lesion area density curves were 0.855 and 0.706, when the size of the lesion =12.80 mm, lesion density =-638 HU, the maximum Youden index, sensitivity and specificity of the maximum. The preinvasive lesion group and invasive lesions group ROC curve showed the lesion size, lesion size, density, solid size, solid density, the proportion of the area under the curve were approximately 0.757, 0.722, 0.780, 0.683, 0.697, when the size of the lesion =13.50 mm, lesion density =-464 HU, solid size =8.05 mm, solid density =-284 HU, the proportion of solid =51.99%, the maximum Youden index, sensitivity and specificity of the maximum. The edge of a group of different pathological lesions(lobulation, short burr, long thorn) was significant difference between the MIA and IAC group in the lobules were more common than INF; MIA, in the IAC group compared with AIS group, short spiculation signs are more common in AIS group than INF and AAH short spiculation signs were more common IAC, AIS; group INF, AAH compared with the long thorn signs were more common. Different pathological lesions within the group(vacuole sign, air bronchogram) had significant difference, vacuoles in the MIA group compared with AIS group syndrome more common in the IAC group; the possibility of the largest air bronchogram. There is a difference between the five groups of pathological types and vessels, AIS, MIA and IAC compared with group INF and group AAH of pleural traction syndrome more likely to pull. INF, AAH group with type I and type II and vessels, AIS and MIA in group III and IV and vessels, while in group IAC IV and V type and vascular relations. All images in the leaves, the burr in the differential diagnosis of adenocarcinoma and inflammatory lesions with high accuracy. All images in the leaves, short spiculation signs in differentiating lung adenocarcinoma invasion with high accuracy of.Conclusion Lesion size and density, solid lesions size and density, solid density, size and proportion of the lesion edge(lobulation, short burr, long thorn), internal lesions(vacuole sign, air bronchogram), pleural indentation sign, vascular lesions and the relationship between the predictive value of pathological classification.