| Research background:Primary bronchial lung cancer is a malignant tumor originating from the bronchial mucosa, gland or alveolar epithelium. Since the last century 80’s, lung cancer has become one of the most common malignant tumor in, according to the latest global cancer statistics, in new cases of cancer, more than 50% of lung cancer, in number of cancer related death, lung cancer accounted for first. Lung cancer from the pathological type can be divided into small cell lung cancer and non-small cell lung cancer of the two categories, and non small cell lung cancer accounts for about 75%-80% of all lung cancer patients. Non-small cell lung cancer can be subdivided for squamous cell carcinoma, adenocarcinoma and so on various pathologic types, which in adenocarcinoma (35%-40%) and squamous cell carcinoma (30%-35%) most commonWith the development of science and technology and medical treatment, there are many ways to treat non-small cell lung cancer, including surgery, chemotherapy, radiotherapy, targeted drug therapy, traditional Chinese medicine treatment and so on.For patients with advanced non small cell lung cancer, targeted therapy and chemotherapy are more commonly used and effective treatment. At present, targeted therapy targeting gene mutation population, and the price is higher, less suitable for the population. Chemotherapy as a targeting therapy is another option, but more side effects, many patients for chemotherapy of the fear, and currently the efficacy of chemotherapy has reached a plateau, curative effect is not more further improved. Combined with the success of the blood tumor consolidation and maintenance treatment model, the concept of solid tumor maintenance therapy can effectively solve the bottleneck problem of chemotherapy efficacy, but there are still some problems in the treatment of drug resistance and drug resistance.In recent years, more and more studies show that Chinese medicine in the treatment of advanced non-small cell lung cancer, to improve the quality of life of patients, prolong the survival time has a certain advantage. Professor Lin Lizhu believes that the long-term clinical practice, the pathogenesis of lung cancer is mainly phlegm, deficiency, blood stasis and toxin ", which led to the" phlegm ", and both are false. Treatment of replenishing qi to invigorate the spleen, resolving phlegm Sanjie, combined with the experience of our hospital cancer center of many tumor experts, founded Yiqi eliminating phlegm for Dafa, Yiqi Chutan recipe based, according to patients with different TCM syndrome types, certificate of addition and subtraction medication in the treatment of non-small cell lung cancer with. And support the validation plan project in the project "10th Five-Year " and "11th Five-Year" in the treatment of non-small cell lung cancer is able to prolong survival, stabilize the tumor, improve the curative effect of quality of life. The Chinese medicine for non-small cell lung cancer treatment can avoid the side effects and drug resistance problem caused by chemotherapy, the crowd is more.Purpose of study:Single center cohort study, this study, by retrospectively collected patient data, all sources of data on patients in the cancer center of the First Affiliated Hospital of Guangzhou University of Chinese medicine hospital department and oncology clinic and to Ⅲ~Ⅳ stage non-small cell lung cancer first-line chemotherapy after curative effect evaluation for stable (SD) patients older than as a clinical study, strict according to the inclusion criteria. The patients were divided into two groups, Benifiting Vital Energy an Eliminating Phlegm formul group (treated by Benifiting Vital Energy an Eliminating Phlegm formul as first-line chemotherapy after maintenance therapy) and maintenance chemotherapy group (on the principle of using original chemotherapy drug maintenance chemotherapy).Through the review (January 2014 to 2016 years 2 months) to study the way of recording data of patients. Regular follow-up and analysis patients were progression free survival (PFS) and quality of life (Karnofsky score, PS score, body weight, lung cancer symptom score and blood toxicity) evaluation of Qi in sputum maintain curative effect and using SPSS 23.0 was used for data analysis.Research results:In this study,71 cases were enrolled in this study,37 cases were treated with Benifiting Vital Energy an Eliminating Phlegm formul,34 cases were maintenance chemotherapy group. There were no significant differences in age, sex, pathological type, smoking status, traditional Chinese medicine syndrome differentiation between the two groups (p>0.05). Combined with the data of the cases, there was no significant difference in progression free survival time (PFS) between the two groups (p>0.05). In two cases of hematological toxicity group were maintained during the treatment of Benifiting Vital Energy an Eliminating Phlegm formul group,8.1% of the patients had bone marrow suppression, all first degree of bone marrow suppression. Maintenance chemotherapy group,52.9% patients appeared to varying degrees of bone marrow suppression, the Ⅲ-Ⅴ myelosuppression of patients have seven (20.5%), P< 0.001, the difference is statistically significant.By contrast before and after treatment in patients with KPS and PS score. Benifiting Vital Energy an Eliminating Phlegm formul group after treatment in patients with KPS and PS scores were stable or improved majority, were 89.2% and 94.6%, compared to maintenance chemotherapy group (64.7% and 70.6%), were statistically significant (p<0.01 and p<0.05). The two groups of patients before and after treatment of weight change, Benifiting Vital Energy an Eliminating Phlegm formul group after treatment than before treatment increased (p<0.01), maintenance chemotherapy group after treatment than before treatment decreased (p<0.01). The difference between the two groups before and after treatment was also statistically significant (p<0.001). According to the weight rating, Benifiting Vital Energy an Eliminating Phlegm formul group rating for the increase of 48.6%, maintaining the chemotherapy group rating for the fall of 61.8%, (p<0.001). According to the lung cancer symptom score of symptoms before and after treatment, the patients in the two groups were compared, Benifiting Vital Energy an Eliminating Phlegm formul group in improvement of lung cancer related symptoms have efficiency is higher than that of maintenance chemotherapy group, with statistical significance (P< 0.05), in addition to the five upset hot symptoms outside, the rest of the symptoms of Benifiting Vital Energy an Eliminating Phlegm formul group effective rate although is generally higher than the maintenance chemotherapy group, but no statistical significance.Conclusion:1. In patients with advanced non-small-cell lung cancer patients to maintain treatment stage, the choice of Benifiting Vital Energy an Eliminating Phlegm formul treatment with respect to the use of the third generation of cytotoxic drugs to maintain chemotherapy, PFS no significant difference in patients with prolonged.2. Benifiting Vital Energy an Eliminating Phlegm formul can reduce the bone marrow suppression more effectively, and can play a better protective effect on patients’ bone marrow function.3. Take Benifiting Vital Energy an Eliminating Phlegm formul for maintenance therapy, the better able to maintain the physical condition of patients, and the patient’s weight to stabilize or improve, better the life quality of the patients, which can affect the patient’s mood and psychological factors, so that patients in the progress of the disease better receive follow-up treatment for the opportunity to.4. Chinese medicine treatment of cancer diseases, with a safe, effective, low toxicity, low cost characteristics. Combined with the results of this study, take Benifiting Vital Energy an Eliminating Phlegm formul to maintain treatment although not on the survival time of the patients have a better benefit, but compared with the western medicine maintenance chemotherapy toxicity and physical condition and treatment of life have obvious advantages so that more patients can get treatment opportunities. |
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