The Research Of Inflammatory Bowel Disease Affects The Hepatic Steatosis

Background:parenteral complication of inflammatory bowel disease (IBD) is taken more and more attention. Hepatic steatosis including nonalcoholic fatty liver disease (NAFLD) has several same pathogenesis with IBD and the parenteral complication about NAFLD was reported rare. The aim of this study was to study the NAFLD incidence of IBD patients and influence factors.Methods:we reviewed 137 patients with Crohn’s disease (CD) and 69 patients with ulcerative colitis (UC) firstly diagnosed in our hospital from 2012.1.1 to 2016.3.1. And we reviewed the hospital physical examination center crowd at the same time with 2:1 ratio by gender, age, body mass index (BMI) match randomly, including 274 CD matched persons and 138 UC matched persons. Comparing of NAFLD detective rate and analyzing other risk factors.Results:the detective rate of NAFLD in CD is higher compared with health matched (10.95% vs. 4.01%, P=0.006). And the detective rate of NAFLD in UC has no difference compared with health matched (10.14% vs. 9.42%, P=0.868). CD patients with BMI normal or underweight, female, have higher NAFLD incidence, while no obvious difference was found between UC and health matched. With the increase of hypersensitive C-reactive protein, NAFLD detective rate of CD patients has a rising trend. In addition, BMI (P=0.034), gender (P=0.047), triglyceride (P=0.026), low density lipoprotein (LDL) (P=0.01) are high risk factors of NAFLD in CD. And gamma glutamyl transpeptidase (GGT) (P=0.05), triglyceride (P=0.032), very low density lipoprotein (VLDL) (P=0.043) are high risk factors of NAFLD in UC.Conclusions:as parenteral complication of IBD, the incidence of NAFLD is high in CD but not in UC. By multi-factor variable analysis, we found that NAFLD detective rate in CD petients is closely related to nutritional indexes such as BMI, while there is no obvious correlation with CRP. This phenomenon may explain that malnutrition, intestinal endotoxemia are likely to be the leading cause of NAFLD in CD. More basic research needs to be further conducted.