Research On The Theory And Application Of Hua-Liu-Zhu-Yu San Combined With Chemotherapy To Treat NSCLC In The Middle-late

Objective:combined with the ancient and modern literature research, this study is based on the theory of traditional Chinese medicine, then through the controlled clinical research, to observe whether the chosen prescription can relieve suffering of non-small cell lung cancer in the middle-late.Methods:using statistical software SPSS 19.0 and SPSS Clementine 12.0 on the Cuban side by summarizing prescription of the treatment of lung cancer by the literature and the modern time to get the frequency and frequency statistics, and make a correlation analysis.In all,we collect 40 Lung clinical criteria in advanced non-small cell cases for this study,18 patients for clinical trial group, the rest 22 cases for the control group, the control group received chemotherapy alone treatment, the treatment group were given side of the tumor stasis combined with chemotherapy, two courses of observation, recording two groups of patients before and after treatment Syndrome change, quality of life, the weight changes, adverse reactions, serum tumor markers (CEA, AFP, NSE, CA199, CY-211) and other related indicators, and statistical analysis.Results:1, the 120 ancient documents and showed virtual medicine appears the frequency highest, at 17.21%, other drug classes in which high frequency for phlegm cough and asthma(15.61%), and the drugs which can regulate the flow of vital energy (13.41%), nourish the medicine (10.81%), temperature in medicine (6.11%), the water moisture penetration medicine (6.11%). Using probability and practicability is good medicine for green husk-three edges.2,108 prescription to collect literature summary appears the frequency highest, accounting for 34.62%, other frequency more than 5% of drug class of phlegm cough and asthma(14.54%), heat medicine (14.03%), the water moisture penetration medicine (8.31%), the medicine for activating blood circulation (6.8%), and the water permeability wet medicine (6.11%), with large probability and practicability is good medicine for all medicine-barbed skullcap herb, Herba agrimoniae-keep palace.3, clinical studies have shown that the treatment group than the control group overall symptoms improved significantly increased (P< 0.05), weight change (P< 0.05), and higher the life quality (P< 0.05); Treatment group appeared gastrointestinal adverse reaction rate than the control group decreased, but the rest of the bone marrow suppression, liver and kidney function had no significant differences of adverse reaction in reducing serum tumor markers CEA, AFP, NSE, CA199, CY-211), and other related indicators in the two groups had no obvious difference;Conclusions:1 HuaLiuZhuYu Prescription help supporting the normal and removing irregular, for the treatment of spleen and lung, in line with the law of prescription literature research.2. HuaLiuZhuYu Prescription in combination with chemotherapy to treat advanced NSCLC than chemotherapy alone has some advantages, can improve the clinical symptoms of lung cancer after chemotherapy of non-small cell, reduce gastrointestinal reactions.