| Objective:In this study, we aim to determine and discuss the relationship between the plasma concentrations of the inflammatory biomarker C-reactive protein and TANK Bind Kinase 1 in Acute Coronary Syndrome patients, analyze the impact of C-reactive protein and TANK Bind Kinase 1 levels on Acute Coronary Syndrome patients.Background It has been demonstrated inflammatory response is in the genesis of coronary heart disease, it’s has also been established that inflammatory response comes as a consequence of coronary artery disease. CAD and inflammation are intimately correlated, in fact inflammation is one of the risk factors for coronary artery disease.Methods:The data were collected from patients aged between 18 and 75 years old admitted to the Department of Cardiology, Zhongda Hospital Affiliated to Southeast University with findings consistent with the diagnosis Coronary Artery disease. A total of 84 patients met the inclusion criteria and were included in the study and according to the levels of Cardiac Troponin I and ECG findings 71 patients were assigned to study group and 13 stable angina patients were assigned to control group. All patients had initial measurement of C-reactive protein and blood specimen collected for determination of TBK1 levels performed upon admission. Full blood work, Triglycerides (TG), Total Cholesterol (TC), High Density Lipoprotein-Cholesterol (HDL-C), Low Density Lipoprotein-Cholesterol (LDL-C), Echocardiogram were assessed within 24 hours of hospitalization. A TBK1 ELISA Kit was used to determine the levels of TBK1. Patient meeting the following exclusion criteria were excluded from the study:1. Age less than 18 years old and more than 75 years old; 2. Patient with acute or with history of chronic inflammatory disease; 3.Any diagnosed infection during the previous 3 months; 4. Treatment for inflammatory or chronic infectious disease at the time of enrollment.Results:A total of 84 patients,30 females and 54 males, aged 65.93±9.64 were included in the study.71 (84.5%) of the total patients were diagnosed with Acute Coronary Syndrome. Among these,15 (17.9%) ST-Segment Elevation Myocardial Infarction,31 (36.9%) Non ST-Segment Elevation Myocardial Infarction,25 (29.8%) Unstable Angina and 13 (15.5%) were set as control. There was no statistically significant difference in the mean age between both study groups (66.47±9.92 years in ACS group and 64.00±11.01 years in control). Measurements of hsCRP showed that 42 (50%) patients had high levels of hsCRP. The distributions (mean; p25, p75) of hsCRP among ACS patients group was (8.46; 2.6,14.33) mg/L and (2.15;1.31,2.55) mg/L among the control group. A statistical significant difference was present between hsCRP levels in ACS patients and control patients (p< 0.002). Higher values of TBK1 were seen in NSTEMI patients,103.96±37.40 ng/L, STEMI patients had mean values of 100.86±28.20 ng/L, while unstable angina and control group had slightly similar values,94.36±36.60 ng/L and 89.19±51.97 ng/L respectively. Difference in TBK1 levels between groups was not statistically significant (p=0.630).Conclusion:Raised hsCRP and TBK1 were major findings in all ACS groups; Levels of hsCRP were highest among myocardial infarction patients; Patients with higher TBK1 and hsCRP levels at the time of admission, have poorer prognosis; TBK1 level could be useful in predicting prognosis and guiding clinical therapy. |
PDF Full Text Request