Clinical Research On MRI-and DSA-based Patterns Of Brain Infarction Due To Stenosis Or Occlusion Of Internal Carotid Artery Or Middle Cerebral Artery

Objective：To make comparisons in the patterns of brain infarctions between patientswith stenosis or occlusion of internal carotid artery (ICA) and middle cerebral artery(MCA), and to explore the potential mechanisms of its pathogenesis, providing strategiesfor acute stroke and preventive intervention.Methods：Seventy-five patients with acute brain infarctions due to ICA or MCAstenosis or occlusions diagnosed by diffusion weighted imaging (DWI) and DSA wereanalyzed retrospectively, and were made comparisons in the cerebral infarction patternwithin the first week of onset.Result：Seventy-five patients were enrolled into this study, thirty-nine patients withstenosis or occlusion of ICA (ICA group) and thirty-six patients with stenosis or occlusionof MCA (MCA group). The occurrence of border-zone infarct (BZI) was15/39(38.5%)and22/36(61.1%) in the ICA and MCA group, respectively, there being a significantdifference (P<0.05). But there was a significant difference in occurrence of perforatingartery infarction (PAI), pial artery infarction (PI) and large territorial infarction (LTI).Compared to MCA group, ICA group displayed a higher occurrence in solitary cerebralinfarction (mainly PI)(P<0.05). In contrast, MCA group have more multiple cerebralinfarction (mainly PI+BZI) relative to ICA group (P<0.05).Conclusions：patients with ICA stenosis or occlusions have a significance differencein brain infarction pattern compared to patients with MCA stenosis or occlusions. Theformer majorly exhibits solitary infarction, whereas the latter display multiple infarction(mainly PI+BZI), suggesting their differences of pathogenesis..