The Significance Of NSE And S100B Protein In Diagnosis And Prognosis Of Acute Craniocerebral Injury

Background and purpose Traumatic Brain Injury is a common form of trauma, and along with the social modernization unceasing enhancement, the incidence of Traumatic Brain Injury increases year by year. Craniocerebral injury always happens at traffic accidents, industrial injury, firearm injury, falling, explosion, etc., including all kinds of blunt and sharp direct blow to the head, etc., often merge of the damage in other parts of the body. With the acute craniocerebral trauma being the important cause of death in young adults and lifelong disability, which brings heavy burden to society and family, has been the world’s public health and social economy problems [1]. The acute craniocerebral trauma and its complications seriously affect the quality of patients’ life, and even directly threaten their lives, therefore, timely treatment of craniocerebral injury is particularly important. At present in patients with acute craniocerebral trauma condition evaluation and prognosis judge relies mainly on the Glasgow coma scale(GCS) score and imaging data, there is no relevant laboratory index [2]. In recent years, the study found that the nervous system related proteins in blood and cerebrospinal fluid in the test for the evaluation of acute craniocerebral trauma degree, adjust the treatment plan and prognosis have important meaning [3-4]. In view of this, this study to investigate the serum and cerebrospinal fluid NSE and S100 B protein expression changes and the relationship between the degree and prognosis of acute craniocerebral trauma, for clinical evaluation of acute craniocerebral trauma degree, providing laboratory basis in diagnosis and prognosis.Methods 89 cases of acute brain injury patients based on admission Glasgow Coma Scale score were divided into light, medium, heavy and severe head trauma group, all serum NSE S100 B protein expression levels and 18 cases in the cerebrospinal fluid were detected within 12 h after injury; The expression levels of serum NSE and S100 B protein in the 20 normal population excluded cases of lung disease and nervous system damage as a control group.Result Compared with the control group, traumatic brain injury patients in each group serum NSE and S100 B protein expression levels were elevated(NSE:P=0.006,S100B:P=0.008). and a special heavy-duty and heavy-set group of patients is higher than the medium and light group(NSE:P=0.027,S100B:P=0.035).Cerebral contusion serum NSE expression levels higher than diffuse axonal injury, subdural hematoma and epidural hematoma in patients(P = 0.035). Serum NSE expression level of GCS score(NSE: rs =-0.327, P=0.024; S100B:rs=-0.417,P=0.032)and Glasgow Outcome Classification(GOS) score(NSE: rs=-0.252,P=0.049;S100B : rs =-0.279, P=0.039) were negatively correlated. Receiver operating characteristic(ROC) curve shows that the area under the serum and cerebrospinal fluid NSE curve was 0.81(95%CI:0.531~0.804)and 0.93(95%CI:0.684~0.828).Conclusion NSE and S100 B protein expression changes can be evaluated as a secondary indicator in reflecting the degree of acute brain trauma, laboratory diagnostic and prognostic, and cerebrospinal fluid levels of NSE is more sensitive than the serum.