Clinical Symptoms And Immunology Inspection Characteristics Of Nasal Cavity Local Allergy

Objective: To investigate the clinical symptoms and immunology inspection characteristics of nasal cavity local allergy.Method: Selected 60 patients as observation group,who had only nasal local allergy symptoms, allergen skin prick test and serum allergen specific Ig E test were negative, 40 allergic rhinitis(AR) patients and 40 healthy volunteers as control groups.To detect Symptom scores and VAS scores, and serum acidophilic granulocyte, allergen skin prick test(SPT), serum allergen specific Ig E test(SIg E), nasal secretions allergen specific Ig E test, nasal mucous membrane excitation test in both observation group and control group,taked the data for statistical analysis.Result: There was no difference(P > 0.05) in the symptom scores and VAS scores of observation group and the AR group. The serum acidophilic granulocyte count and the percentage in the AR group were higher than in the observation group(P < 0.05). Allergen skin prick test and serum allergen specific Ig E test of observation group and healthy volunteers group were negative, while they were all positive in AR group.The positive rate of nasal secretions dust mites and pollen allergen was 90%(54/60) in observation group it was 100% 40/40 in the AR group.In dust mites or pollen allergen proocation tests, after stimulating test bilateral nasal minimum cross-sectional area to reduce more than 25% was 53.34%(32/60), bilateral nasal airway resistance increased more than 100% was 90%(54/60), can be identified as the nasal mucosa stimulating test positive.Conclusion: For patients with the typical medical history and symptoms of AR, but allergen SPT and serum allergen SIg E test were negative, there was local specific hypersensitivity in nasal mucosa, but the reaction was not accompanied by systemic sensitization.Combined with nasal secretions allergen SIg E test or allergen nasal mucosa proocation tests positive, couid be diagnosed as local allergic rhinitis.