Expression And Clinical Significance Of SIPA1 Protein In Different Cervical Tissues

Objective:To explore the expression of Signal-induced proliferation-associated protein 1(SIPA1) in normal cervical tissues, cervical intraepithelial neoplasia(CIN) tissues and cervical cancer tissues and its clinical significance.Methods:Collected the pathology paraffin block specimens and surgical treatment in the Department of Gynecology in First Hospital of Shanxi Medical University, during June2012 and 2015 June, including cervical intraepithelial neoplasia variable tissue specimens of 30 cases, cervical cancer tissue specimens of 46 cases, and during the same period for uterine fibroids hysterectomy pathology of 10 normal cervix tissue samples as control. Pathological diagnosis of all tissue paraffin blocks was based on the known diagnostic criteria. Applied immunohistochemical method to detect SIPA1 protein expression in normal normal cervix, CIN and cervical cancer tissues to explore its relationship with clinicopathological features.Results:1. Expression of SIPA1 in normal cervical tissues, cervical intraepithelial neoplasia tissue and cervical cancer tissue expression was gradually increased, the differences between the three groups had significant difference(P < 0.001), expression in normal cervix group and cervical cancer group, the difference was statistically significant(P <0.01), expression in CIN group and cervical cancer group, the difference was statisticallysignificant(P < 0.01), expression in normal cervix group and CIN group, the difference was no statistically significance(P > 0.05).2. SIPA1 protein expression in cervical cancer group and the relationship between the clinical and pathological features. SIPA1 protein expression in cervical cancer age,clinical stage, tumor size, cervical stromal invasion depth and the degree of tumor differentiation, histological type, the difference was no statistically significance(P >0.05),expression in lymph node positive cervical cancer tissues was significantly lower than that in lymph node negative cervical cancer tissue, the difference was statistically significant(P=0.001). The expression of SIPA1 protein was negatively correlated with lymph node metastasis(r=-0.506,P<0.001).Conclusion:1.The expression of SIPA1 protein in normal cervical tissues, cervical intraepithelial neoplasia and cervical cancer was gradually increased, which may be related to the occurrence of cervical cancer.2. The expression of SIPA1 protein in cervical cancer was negatively correlated with lymph node metastasis, which may be an index to evaluate the cervical cancer lymph node metastasis.