Correlation Between Serum Uric Acid Levels And Gensini’s Score In Patients With Coronary Heart Disease

Objective: To investigate the correlation between serum uric acid level and the severity of coronary heart disease(CHD) by Gensini’s score in patients with coronary heart disease.Methods: We investigated 526 patients(male: n =282, female: n=244) who suspected to have coronary heart disease and underwent coronary angiography in the Second People’s Hospital of Chengdu from OCT, 2014 to OCT, 2015, and clinical data were collected. CHD group, n=222 patients with coronary angiography confirmed diagnosis and control group, n=304, which contained subjects without luminal stenosis and subjects with luminal stenosis ≤ 50%.The severity of coronary atherosclerosis was defined by Gensini’s score. The levels of serum uric acid and other basic clinical conditions were compared between CHD group and control group.the prevalence of CHD and Gensini’s scorewere compared between 4 groups(A, B, C,D),which divided subjects by quartile of serum uric acid level. Screened out the correlative factors for the incidence of CHD and Gensini’s score by Spearman analysis. Binary logistic regression analysis was employed to explore the independent risk factors to the morbidity of CHD. Multiple stepwise linear regression analysis on Influence factors of Gensini’s score in patients with CHD.Results: The level of serum uric acid in CHD group was higher than that of control group, 354.47 ± 94.74 mol/L vs.330.60 ± 89.45μmol/L, P < 0.05. In Different gender,the level of serum uric acid in CHD group was significantly higher than that in control group, P < 0.05. After divided subjects into 4 groups(A, B, C, D)by quartile of serum uric acid level, the prevalence of CHD and Gensini’s score in the top quartile(D)were much higher than in control group, P<0.05. The Gensini’s score in patients with CHD increased with the increasing level of serum uric acid, P=0.038. Spearman’s correlation analysis indicated that, in patients with CHD, the serum uric acid levelwas positive correlated with Gensini’s score(r=0.183, P=0.008), and partial correlation analysis showed that serum uric acid level was still positive correlated with Gensini’s score(r=0.091, P=0.049) while the age and gender were under control.Binary logistic regression analysis revealed that serum uric acid level did not associated with the morbidity of CHD independently(P>0.05). Multiple stepwise linear regression analysis demonstrated that serum uric acid level was significantly independently associated with Gensini’s score(b=0.059,P=0.037) in paitients with CHD.Conclusion: In patients with CHD, there is a positive correlation between serum uric acid level and the severity of coronary atherosclerosis as measured by Gensini’s score, and the serum uric acid level is a independent influencing factor for Gensini’s score.