Risk Assessment Of Coronary Heart Disease Patients With Nomal Low-density Lipoprotein Cholesterol

Objective: The study aims to investigate the risk factors in coronary heart disease(CHD) patients with nomal low-density lipoprotein cholesterol(LDL-C).Methods: Totally 111 individuals undergoing coronary angiography with nomal LDL-C(less than 3.1mmol/L) participated in this controlled clinical trial, including 55 cases in the coronary heart disease(CHD)group,56 cases as the control group. Plasma concentration of lipid related index:triglycerides(TG), total cholesterol(TC), high-density lipoprotein cholesterol(HDL-C), apolipoprotein A-I(apo A-I), apolipoprotein B(apo B), apolipoprotein E(apo E), apolipoprotein C-III(apo C-III), and inflammation related index: amyloid A(SAA), adiponectin(APN),sphingosine-1-phosphate(S1P) were tested and compared between two groups. Calculating related index: non-HDL- C, the ratio of LDL-C/HDL-C,apo B/apo A-I, HDL-C/TC and SAA/apo A-I were also measured and analyzed.Results: The two groups in smoking, drinking, BMI, LDL-C, TC,apo B, apo E, apo C-III, SAA, APN, S1 P, non-HDL-C, LDL-C/HDL-C,HDL-C/TC and SAA/apo A-I had no statistical difference(P > 0.05). But the age, male proportion, diabetes prevalence, hypertension prevalence,TG and apo B/apo A-I were statistically significant higher in CHD group than in control group(P<0.05), HDL-C and apo A-I were less in CHD group than in control group(P < 0.05). Logistic analysis indicated that in addition to traditional risk factors as age, sex, diabetes and hypertension were independently related to CHD(P < 0.05), TG was also an independent risk factor of CHD(HR, 2.771; 95% CI, 1.105 to 6.948, P < 0.05).Conclusion: In populations with normal LDL-C concentration,traditional risk factors age, sex, diabetes and hypertension are still correlated with CHD. But TG is an independent risk factor and may be a better index to predict CHD.