A Correlation Study On Polymorphism Of Suicide Candidate Gene With Neuroimaging

Suicide is an increasing problem and has attracted more and moreattention at home and abroad. Though the genetic study on suicidalbehavior has been for a long time in domestic and foreign country, noobvious breakthrough and formal consensus exists to date in associating aneurobiological mechanism with suicide. Functional brain imaging offers anon-invasive in vivo direct estimation of detailed brain structure, regionalbrain functioning and estimation of molecular processes in the brain.Recently, some researchers raised a concept of imaging genetics whichuses physiological imaging technology as a phenotypic analysis to evaluatethe genetic variation and investigate how genes influencethe brain’s neural structure and function, as well as the reasons contributingto psychological problems. Moreover, it can explore the influence ofdifferent gene polymorphism on neural processing of emotionalinformation and the transmission of neural information in different brainregions through technique of imaging genetics. However, there is noimaging genetics study on suicidal behavior at present, and the present study is focused on association of suicide candidate gene and neuroimaging.The neural path system of suicide candidate genes is involved with13candidate genes from8systems, including serotonin, brain-derivedneurotrophic factor(BDNF), the hypothalamic-pituitary-adrenal axis(H-P-A), epinephrine, dopamine, glutamate, GABA, polyamines. The genepolymorphisms and interaction of these different gene polymorphisms areinvolved in emotion regulation, code, cognitive function, execution andmemory, mainly distribute on emotion regulation. Neural circuitry ofemotion regulation mainly involves the interaction between dorsal-ventralprefrontal cortex, prefrontal lobe-amygdale, cortex-limbic system, and thedysfunction of emotion regulation circuits can lead to emotional disorders,eventually could produce impulse self injurious behavior(SIB) and suicidalbehavior. Therefore, we can explore the correlation of gene polymorphismwith brain function and behavior using technique of imaging genetics, andthus to reveal the potential neurobiological basis of suicidal behavior fromthe“gene-brain-behavior”model.