| ObjectiveIn order to investigate the comprehensive influences of KAATSU exercise on organism, especially on cardiovascular system. Evidence-based and empirical studies were used to explain the problem.Part1. Meta-analysis: Through literature retrieval, multiple independent findings about resistance training with blood-flow restriction were filtered and combined, aim to evaluate the influence of blood-flow restriction exercise on cardiovascular system.Part2. Empirical studies: Implemented 8 weeks resistance training with blood-flow restriction, detected indexs related with cardiovascular system, neuromuscular system, energy metabolism, inflammation. In order to evaluate biological effects of resistence training with blood-flow restriction on organism and provide new theoretical and experimental reference for public health.MethodsPart1: Use “KAATSU, Blood flow restriction, Cardiovascular” as keywords to search in Pub Med, High Wire Press, Plos, Bio Med Center, Web of Science and other databases. According to the inclusion and exclusion criteria certain evaluation criteria, 6 studies were filered and quality assessed by Rev Manger 5.3. Part2: 40 healthy adults were randomly divided into KAATSU training group and control group. The training program lasts 8 weeks. The level of body composition and anaerobic power of lower extremity were detected by Body composition analyzer and Wingate method. The related factors were determined by ELISA method. Blood routine examination and glucose and lipid from blood were also analyzed before and after Training.ResultsPart1: 6 studies were brought into Meta-analysis, and outcomes divided continuous variables and dichotomous variable. Continuous variables which followed by random effects model(I2=82%, P<0.000) showed that: training with blood-flow restriction has no effect on heart rate, systolic blood pressure, diastolic blood pressure and cardiac output. Dichotomous variables followed by fixed effects model(I2=12%, P=0.33)showed that: training with blood-flow restriction can improve the maximum oxygen uptake levels(RR=3.03, 95%CI:1.85~4.96) and vascular function(RR=3.23, 95%CI:1.89~5.53).Part2:(1) As compared with no KAATSU Training group, the plasma VEFG in KAATSU Training group was significantly increased(P<0.05).(2) As compared with no KAATSU Training group, the average values of serum total cholesterol was decreased significantly(P<0.05).(3) After 8 weeks KAATSU training, the peak of upper limb anaerobic power frequency laps significantly increased(P<0.05); Compared with no KAATSU group, there were significant increase in the peak and the relative peak of upper limb anaerobic power(P <0.01).(4) After 8 weeks KAATSU Training, the average body age(P<0.01), BMI, body fat % in KAATSU Training group were significantly decreased(P<0.05).(5) After 8 weeks KAATSU Training, the average of relaxed upper arm girthh(P<0.05) and thigh girth(P<0.01) were significantly increased.Conclusions and Suggestion:Part1: Meta-analysis results showed that training with blood-flow restriction promoted vascular function and no negative impact on cardiovascular system.Part2:(1) The KAATSU training could increase the secretion of vascular endothelial growth factor(VEGF) and NO, benefited to promoting vascular tone and improving endothelial function.(2) In terms of lipid metabolism, after 8 weeks resistance KAATSU training, the average values of serum total cholesterol and triglyceride significantly decreased, while the plasma lipoprotein lipase(LPL) and pyruvate dehydrogenase kinase(PDK4) synergistic increased, which promote the fat decomposition. Thus we can infer that KAATSU training could improve blood lipid metabolic disorders and prevent cardiovascular disease. Meanwhile, the KAATSU training reduced body weight, BMI and body fat percentage significantly, benefited to optimizing body composition, controlling body weight and prevention of obesity. |
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