Cross-over Design And Analysis With Bivariate Endpoints

In this paper, we propose the method of statistic analysis in crossover design with bivariate endpoints. The bivariate endpoint contains normal endpoints and binary end-points. In the section of normal endpoints, based on the existence of the carry-over effects, the corresponding method of the hypothesis test and the the sample size calculation axe given. In the section of binary endpoints, based on the Mainland-Gart test, the cor-responding method of the hypothesis test and the sample size or power calculation axe given. In the end, the calculations of sample size determined and power are facilitated by R programs.