Synthesis And Study Of The Derivatives Of The Topramezone

Benzoyl pyrazoles compounds is a kind of HPPD inhibitor herbicides and has the characteristics of unique mechanism of action, high efficiency, low toxicity, since the beginning of the seventies of the 20 th century was found to become the market's most development potential and prospects of herbicidal compounds and the molecular design and synthesis, structure effect relationship research is hotspot of current pesticide research and development.This paper provides an overview of the nearly 10 years to benzoyl pyrazoles compounds in the field of pesticide research and development research progress and status, summarize the literature on to effects of topramezone for derivatives of the pilot of the more comprehensive, and analyzes the structural characteristics of Benzoylpyrazoles herbicides. Based on to further search for compounds with biological activity of benzoyl pyrazoles, benzoxazole ketone grass as a lead compound, by way of "sub activity structure splicing principle", active fragment into benzoyl pyrazoles compounds, synthesized four kinds of a total of 29 novel benzoyl pyrazoles compounds.All the target compounds are characterized by IR, 1HNMR, 1CNMR and MS. The bactericidal activity of the target compounds were tested, the results showed that most of the compounds showed certain antibacterial activity of wheat scab, Fusarium oxysporum and Rhizoctonia solani, which at the concentration of 50 ?g/m L, inhibition of wheat scab, Rhizoctonia solani rate of compound A5 were 48.6±2.2%, 57.5±2.3%; inhibition of wheat scab pathogen, Rhizoctonia solani rate of compound B4 were 53.6±2.3% and 55.2±1.6%; in addition, A6, B2, B5 inhibitory compounds on wheat scab rates were above 45%, compounds B6, B7 inhibition of Rhizoctonia solani rate in 40% above; at the concentration of 200 ?g/m L, compound A5 inhibition of citrus canker bacteria was 51.1±2.1%; in addition, compounds A5, A6, B2 on the inhibition of rice bacterial blight rate was above 35%, the compound A10 The inhibition rate of citrus bacterial strain was 36.3±1.4%.