The Preparation And Researches Of Nano-hydroxyapatite/Poly-?-caprolactone Composite Porous Scaffolds

The most widely used bone scaffold material are biodegradable polymers and bioactive ceramics.poly-?-caprolactone(PCL)has advantages of low melting point,easy to process,low cost.nano-hydroxyapatite(nano-HAP)has good mechanical properties,biological activity,biocompatibility and bone inductivity etc.From the perspective of nanotechnology,nano-HAP with large specific surface area contribut to the excellent ability of induction of seed cell growth,proliferation and differentiation.In this study,poly-?-caprolactone(PCL)and nano-hydroxyapatite(nano-HAP)are considered as the research object,with photo as the matrix material,nano-HAP as nanometer reinforced material,making them complementary.Selective laser sintering(SLS)technology is used to fabricate PCL,nano-HAP/PCL composite porous scaffolds and the related properties are studied.In this paper the main work and innovation are as follows:PCL porous scaffolds are fabricated via selective laser sintering.the molecular structure of PCL did not change before and after sintered and with the increase of laser power,the phase composition of the PCL scaffolds also did not change,but the crystallinity decreased.At the same time,the porosities reduced from 90.98±2.7% to 76.84±1.48%,the compression strength increased from 0.23±0.02 MPa to 9.03±0.05 MPa.the most suitable technological parameters of sintering are 3-5 W.Cell toxicity experiment results show that the relative increment rate are higher than 94% and cell toxicity level is 0.However,there is not found a kind of bone apatite formation on the porous scaffold after immersed in simulated body fluid(SBF)solution.In order to make up for the inperfactions of the PCL porous scaffold with poor mechanical performance and lack of biological activity,nano-HAP as a reinforcing phase are added into the PCLS matrix in this study.Nano-HAP/PCL porous scaffolds are fabricated via selective laser sintering.It is found that with the increase of the content of nano-HAP,the compression strength of the porous scaffold increased compared to the PCL porous scaffold.Furthermore,the composite porous scaffolds own excellent bioactivity and cell biocompatibility.