Study On The Route Of The Synthesis For Florhydral

Perfumers are widely used in medicine,food,drinks,cigarettes,cosmetics and other industries,are closely related with people' s daily lives.With the rapid development of economy in the world,people's consumption level is also increasing,the quality of food and daily necessities people seeking is higher.However,as an important part of food and daily necessities,these factors will absolutely lead a rapid development of perfumery industry in the world.As a precious spice,Florhydral has an important position in the cosmetic industry.The synthesis route of florhydral was explored,Inexpensive cumene as raw material,Paminopropylbenzene have been produced by Mixed acid nitration and Iron reduction;Acylation of nitrogen is carried out using acetic anhydride,after liquid bromine for ortho-substitution,The diazotization-deamino-reduction reaction will take place to obtain Bromo-cumene,After the formation of Grignard reagent with magnesium,The Michael addition reaction with crotonaldehyde will be occurred,Thus,Florhydral was obtained.The products and intermediates were characterized by FT-IR and 1H-NMR.The optimum reaction co nditions of oxidative bromination were obtained by orthogonal experiments: Liquid bromine and raw materials ratio is 0.65:1,Hydrogen peroxide and the ratio of raw materials is 2:1,;Controlled drop of liquid bromine temperature around 40 ?;The temperature of the dropwise addition of hydrogen peroxide was about 65?;The optimum conditions of diazotization-deaminase reaction were as follows: Hydrochloric acid and raw materials ratio is 2:1;The ratio of hypophosphorous acid to raw material is 5:1;The diazotization reaction temperature was controlled at about 5?,and the temperature at which the hypophosphorous acid was added was set at 50??...