The Study On The Preparation Process And Quality Standard Of Fengshi Hantong Tablets

Fengshihantong tablets are exclusively produced by Tianjin Tongrentang Group Co.,Ltd,and have the effects of dispelling wind and cold,dehumidifying and promoting blood circulation and nourishing liver and kidney.This article mainly researches the optimization of the production process and the improvement of the quality standard of the Fengshihantong tablets.In the granulation process,a one-step granulation method replaces the existing two-step wet granulation method,and the optimal process parameters are as follows: the relative density of the extractum is 1.20-1.30,the rotation speed of a peristaltic pump is 20-35r/min,the atomization pressure is 0.20-0.40 MPa,and the material temperature is 50-75?.In the coating process,the optimal film coating parameters are as follows: the concentration of the coating liquid is 8%,the rotation speed of the peristaltic pump is 10-30r/min,the air inlet temperature is 80? and the tablet bed temperature is 50-60?.Microscopic identification of pilose antler,qualitative identification of radix scutellariae,Angelica sinensis,red paeony root,large-leaved gentian and Astragalus mongholicus and HPLC of the tablets are adopted.The chromatographic conditions of HPLC are as follows: the chromatographic column is phenomenex Luna C18(250×4.6mm,5?m),the column temperature is 40?,the flow rate is 1.0mL/min and the detection wavelength is 262 nm.The content of the diversine in each Fengshihantong tablet is not less than 0.34 mg.This paper mainly from the preparation process and quality standards in two aspects of study.The preparation process of the thin film coating technology simple production process,short cycle and lower the risk of microbial contamination of one step granulating and has the advantages of simple operation,high production efficiency,compared with the existing production process not only artificial energy and low cost and increase the adapt to the crowd.The solution is simple and convenient preparation method and test method of the quality standard,and the test method of durability test and sampling precision,repeatability,stability and recovery test,thus proving test method specificity,good stability and feasibility.