Synthesis Of A Fluorescent Sensor Based Derivative Of Naphthalene And Application In The Detection Of Ions And Explosives

In the life system,some of the cations and anions are involved in various physiological or pathological processes.In order to better study and understand their impact and influence on the physiology and pathology,developing effective detection methods has become a current research hot spot.Fluorescencet molecular probe has attracted great attention because of the advantages including high sensitivity,noninvasive sample preparation,real-time situ detection and so on.Hence it has been widely applied to the analysis of biological chemistry,biology and medicine and other research fields.This paper design and synthesize two kinds of new fluorescent probes,through infrared spectrum,nuclear magnetic resonance hydrogen spectrum,nuclear magnetic resonance carbon spectrum,mass spectrometry and X-ray single crystal diffraction to confirm the target productws.These two kinds of probes can be used to specific recognize F^-,CN^-,Ag⁺,TNT and TNP.The details are summarized as follows:In the first chapter,the fluorescencent phenomenons and the related knowledge about fluorescencent probe are simple overviewed,the design methods of fluorescencent probe and detection principles are summarized.Meanwhile,the research status about naphthalene derivatives based fluorescent probe molecules in recent years is analyzed.According to information above,we put forward the topic basis and design ideas.In the second chapter,because 2-naphthalene acetic acid and 2-amino benzothiazole are good fluorophors and anion receptors,fluorescent probe molecules P₁ was designed and synthesized containing amide bond.According to the deprotonation by CN^-and coordination between Ag⁺and amide bond,we achieved the specific recognition for CN^-and Ag⁺under two kinds of channels of fluorescencent spectrum and UV-Vis absorption spectrum,respectively.In addition after adding the CN^-and Ag⁺,the fluorescence of solution changed obviously.The probe has a good sensitivity and the limit of detectation is up to 0.44?M and 0.2?M respectively.Further,the mechanism of recognition was discussed by the experiment of competition,Job'Plot curve,nuclear magnetic titration and X-ray photoelectron spectroscopy?XPS?.In the third chapter,a novel anionic fluorescent probe P₂ containing naphthalene schiffer base was designed and synthesized.Under the UV-Vis absorption spectrum and fluorescence spectrum,the probe has a good selective recognition towards F^-and CN^-,and after adding F^-and CN^-,the color of solution had a obvious change,which can be used as excellent colorimetric probe for F^-and CN^-by naked-eye recognition.In addition,we also discussed the mechanism of recognition by the experiment of nuclear magnetic titration and Job's Plot titration.Meanwhile,it can also qualitatively and quantitatively detect explosives such as TNT and TNP.4.In the last chapter,a summarization about the research work was concluded,and the research direction was forecasted.