The Research Of Liquid-Based Cell Automatic Tableting System

With the rise of liquid-based cytology,liquid-based thin-layer cell technology has been widely used in vary cytopathological detections.Currently,developed countries like Europe and the United States have developed more advanced liquid-based cell automatic tableting technology,but related equipment are so expensive that most domestic hospitals,especially small and medium-sized hospitals can't afford the high costs.Therefore,conventional methods like pap smears with many drawbacks are still used in most hospitals,which have low tableting efficiency and even may result in the high rate of false positive and false negative diagnosis.With the aim to change the backward status of liquid-based thin-layer cell technology,this work aims at designing an automatic tableting system based on liquid-based thin-layer cell technology,with which the tableting process can be full automatically performed and further used in the tableting of human exfoliated cells such as cervix,body fluid,mucus,urine,and fine needle puncture,etc.In order to fulfill the process including cell filtration,separation,transfer and production,a series of subjects containing mechanics,electrics-optics and aerodynamics should be applied spontaneously.Herein,the most important is the separation technology,namely,the membrane filtration.However,in the current filtration technology,serious pipeline blockage happens here and there,which should be improved efficiently.With full investigations of previous equipment and skills,by rationally designing the structure of the cell filter,it is hopeful to improve the collection method of the cell preservation solution,further,avoid the blockage of the pipeline.In this work,according to the characteristics of the cell filter structure,combined with the knowledge of mechanical principles and mechanical design,a three-dimensional model of the cell filter together with the mechanical structure of the liquid-based cell automatic tableting system has been established through CATIA.Besides,to ensure the rationality and reliability of designed structure,we chose Hypermesh to make necessary finite element analysis about its mechanics of machinery to the mechanical structure of the main parts.First of all,a complete human-computer interaction system should be configured and the steps are described as below:(1)according to the requirements for motion control of the liquid-based cell automated tableting system,AVR microcontroller is chosen to be the main control chip of the control system;(2)OMRON photoelectric position sensor acts as position feedback device;(3)selecting an appropriate motor driver and designing the PID control algorithm based on RBF neural network for the drive motor;(4)adding LCD liquid crystal screen to display.Secondly,the system should ensure that cells are loaded on the slides in the most ideal form.To achieve this and according to the technical characteristics of membrane separation,the control program are rationally designed by well configuring the control system hardware.The control program is written in C language and described as follows:(1)splitting the action flow,programming them and then making modularizations;(2)embedding the motor control algorithm into the control program.Notably,the liquid-based cell automatic production system designed in this work has been clinically applied in many domestic hospitals,which proves that the system has excellent tablet production effect,stable and reliable performance,high efficiency,low cost,and meets design requirements.