The Research Of Improving Hair Follicle Reconstruction In Vivo Model

With the development of society,people's living standards continue to improve,and the constant pursuit of quality of life has led to an increasing demand for high-end clothing.Nowadays,many high-end clothing products of raw materials-animal fur,Wool,Shui Diaomao,for example,with fur rich,beautiful,warm and good,durable,become an important raw material for the textile industry.Therefore,they are also a special and important livestock product.Because of the high profit return of fur farming,the for animal breeding industry has been developing rapidly,and all kinds of fur economic animals have attracted much attention.The quantity and quality of hair produced by animals are the main factors that affect the economic benefits of fur production,and determine the market potential and prospect of the whole industry.In the process of production,but,animals often lose hair and remove hair,which is often an important problem for breeding personnel.It is closely related to environment,nutrition level,hormone secretion,feed,parasite,fungi,bacteria and so on,and the reason is very complicated.Also,there are many animals due to their hair follicles hypoplasia,leading to animal alopecia and congenital hypotrichosis disease.We now study how to improve the yield of a fur animal hair,most of them are from the breeding of the prevention and treatment of hair loss disease animal angle.In this paper,we use the advanced research achievements and new technologies at home and abroad,and use new scientific methods,by analogy,to find a new angle,and explore new models and methods to rebuild hair follicles through stem cell transplantation to improve the animal hair quality and quality.In recent years,scientists have used tissue engineering methods to provide many successful cases for the clinical treatment of organ regeneration in hmans.Based on this more advanced model of scientific achievements transformation,the model of hair regeneration,which has been focused on by clinicians and researchers,has become a new hot spot in scientific research in the treatment of human baldness and alopecia disease.At present,the research on the construction of regenerative hair in the skin defect by injection,chamber and transplantation,which had been reported in nude mice,has been more mature.However,there are advantages and disadvantages in using them.Equal principle,we envision a new attempt to use tissue engineering methods to treat mammalian alopecia diseases or to increase the hair productivity of the economic animals directly through the regeneration of follicles.But both the construction of animal models and methods of operation need to be improved.Therefore,the research contents are as follows:1?Optimizing the method for obtaining separation of seed cells(skin stem cells).The previous study was based on the isolation of individual epidermal and dermal stem cells to transplant.But by reducing the digestive function of enzymes,it can be improved to form a mass of epidermal cells,and further increase the number of stem cell survival,so as to improve the efficiency of hair follicle regeneration.2?Exploring the best operation plan of cell transplantation.On the basis of the previously reported experimental methods,the most suitable method of operation in production practice is studied.3?Constructing the animal model conforming to the practice of production.By constructing an animal skin defect model,the optimum percentage of seed cells required per unit area could be calculated,and reduce damage to host animals,and to further improve the application of animal models required in practice.4?Calculate the number of hair units and observe the hair condition,observe the growth of hair follicle under electron microscope,and HE staining was used to verify the formation of normal skin structure.