Effect Of Changes In Renal Function Related Indicators Before And After Surgery In Patients With Hepatic Hydatid

Objective:1.By collecting30cases of hepatic hydatid patients and30control patients related indicators of renalfunction prior to surgery to investigate whether patients with hepatic hydatid affect renal function.2. By observing the patient before liver hydatid surgery, postoperative renal function changes relatedindicators to explore whether the removal of liver hydatid antigen impact on renal function.Methods:1. Collection of the First Affiliated Hospital of Shihezi University of Hepatobiliary Surgery and YiliPrefecture Friendship Hospital of General Surgery admitted in December2012and June2013during the30cases of hepatic hydatid patients, and select the corresponding period in hospitalized patients withnon-hepatic hydatid30cases in the control group,detected blood urea nitrogen,serumcreatinine,blood?2-microglobulin and microalbuminuria,urinary N-acetyl-?-D-glucosaminidase, urinary?2-microglobulin, urinary albumin levels and comparison between the two groups.2. Collection of the First Affiliated Hospital of Shihezi University of Hepatobiliary Surgery and YiliPrefecture Friendship Hospital of General Surgery admitted in December2012and June2013during the30cases of hepatic hydatid patients, detected before surgery and after surgery one month, three months, sixmonths urinary N-acetyl-?-glucosaminidase levels and conducted comparing preoperative andpostoperative.Result:1. Patients with hepatic hydatid collected16males (53.3%) and14females (46.7%), male to female ratio ofabout1.14:1, the average age of40±4.7, first diagnosed26cases of liver hydatid disease,2times surgery1cases,?3times surgery in3cases, including a four surgical patients; hydatid located right liver17cases,6cases of left liver, left and right liver involvement while7cases; intrahepatic single lesion in18cases,12cases of multiple lesions. Select the same period of non-hepatic hydatid of patients,18males and12females; the average age of38±3.9,2groups of patients were not hypertension, diabetes, autoimmunediseases and kidney disease, their age, gender and other general information no significant difference (P>0.05). Hepatic hydatid group BUN (2.33-6.25mmol/L), Scr (46-96.3umol/L) levels were normal,urinaryalbumin negative, liver hydatid urinary NAG (15.98±0.88u/g) higher than the control group (7.37±1.24u/g),and the difference was statistically significant (P <0.05), serum ?2-MG, urinary mALB, urinary?2-MG with the control group, the difference was not statistically significant (P>0.05).2.30patients with hepatic hydatid group of8patients (26.7%) underwent subadventitial totalexocystectomy,22cases (73.3%) underwent the traditional surgical approach.Patients were followed upafter a month of urinary NAG (15.75±0.55u/g), after three months of urinary NAG (12.36±0.68u/g), after six months of urinary NAG (7.21±0.95u/g), NAG returned to normal after six months, compared with the pre-operative difference was statistically significant (P <0.05).Conclusion:1. Urine of patients with hydatid disease of the liver NAG activity higher than normal may be correlatedwith allergy response in patients with hydatid disease of the liver cause early kidney damage.2. Early kidney damage in patients with hepatic hydatid caused by the body's allergic reaction may be dueto the removal of liver hydatid antigen restored.