| Objective: Malignant tumor is one of the most serious diseases, and becomes the main reason for the high death rate of urban residents in our country. Insomnia is to difficult to fall asleep within 30 minutes,or to difficult to maintain sleep,and wake up with a sense of fatigue,for at least 3 times within a week.So we conducted a survey among the Malignant tumor patients in Hebei Provincial Tumor Hospital to investigate the overall incidence of cancer-related insomnia and anxiety; related factors of insomnia; relationship between cancer-related insomnia and quality of life, to provide reference for clinical treatment.Method:1 Select 103 cases of advanced cancer patients who were treated in Fourth Hospital of Hebei Medical University from 2014-12 to 2015-15. They were confirmed advanced cancer by pathological and radiological diagnosis and had no mental illness before.2 Collect disease information and demographic data of the 103 patients. All the subjects themselves completed the following questionnaires: PSQI. According to the length of stay,divided all the patients into two groups.Two groups of patients were carried out with hematology and ECG examinations before treatment.And all the result were normal,and the group which treated with drugs without taking psychotropic drugs at least 14 days.3 The experimental groups was treated with zopiclone 7.5mg,qd,lasted for 3 weeks,the other patients which in control group were treated with placebo.All the patients filled the form of Pittsburgh Sleep Quality Index(PSQI) and Self-Rating Anxiety Scale(SAS) before and after treatment.In order to analyze the sleep time,sleep quality,etc.In order to judge the efficacy,we calculate PSQI and SAS scores before and after treatment.4 Statistical analysis: Using SPSS13.0 software, the frequency was used to describe the demographic characteristics of patients. Select 9 variables such as age, gender, culture level, etc. Use the single factor variance analysis methods to analyze the relationship with insomnia. Using Logistic regression method to analyze the risk factors of cultural degree, informed level and the economic burden, etc. Using Spearman correlation analysis methods to analyze the degree of informed and PS scores and the relevance of the insomnia, insomnia related to the quality of life in the table. Standard test to P <0.05 is of significant difference, P >0.05 is of no statistical significant.Results:1 After 3 weeks of treatment,the experimental group of insomnia was significantly better than the control group,the difference was statistically significant(P<0.05), while the same to the experimental group of anxiety.2 Analyze age, gender, place of residence, cultural level, pathogenic site, the economic burden and informed level as 9 grouping variables. The result show that: the informed level and PS scores have highly significant impact on the onset of insomnia(P<0.05), while, the age, residence, cultural degree and the economic burden have no significant impact on the onset of insomnia(P > 0.05).Informed level and PS scores are the independent risk factors for the onset of insomnia.3 Before treatment, the experimental group and the control group were had no difference(P>0.05); the experimental group was better than the control group,result showed that zopiclone can significantly improved the malignant tumor related insomnia(P<0.05).In the experimental group,there were significant differences between the control group and the sleep time, sleep quality, sleep time, daytime dysfuntion.Conclusion:1 Zopiclone has the significant improvement with insomniac who was malignant tumor,but has nothing to do with cancer-related anxiety.2 Gender, educational level, PS score, informed level have a significant impact on cancer-related insomnia.3 The experimental groups was better in sleep duration,sleep quality and daytime dysfunction. |
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