The Clinical Significance Of Hs-CRP,Cortisol And SICAM-1 In Senior Coronary Heart Disease Patients Combined With Depression And Monitoring

Objective: To explore the level changes of serum hs-CRP,cortisol and sICAM-1 in senior coronary heart disease patients combined with depression and analyze correlation between these factors and depression scale.Method:Research object:1 To select 60 cases senior coronary heart disease patients combined with non-depression as control group(group A),select 69 cases established senior coronary heart disease patients combined with depression as observation group(group B);2 According to coronary heart disease lesion degree,observation group(group B)include 32 cases stable angina pectoris patients combined with depression(group C)and 37 cases acute coronary syndrome patients combined with depression(group D);3 According to self-rating depression scale,observation group(group B)include 48 cases senior coronary heart disease patients combined with mild-moderate depression(group E)and 21 cases senior coronary heart disease patients combined with major depression(group F);We select all research object above from January 2013 to June 2013 in The First Hospital of Hebei Medical University cardiology department,cardiac function? level,age>60,compare basic date between group A and group B: sex,body mass index,blood pressure,blood lipid,and detect the level of serum high sensitive C reactive protein,cortisol and soluble intercellular adhesion molecule-1,analyze correlation between these factors and depression scale.Detect method:1 Application of depression scale: All patients in the reaserch are involved to fill in the self-rating depression scale and evaluate their psychological state,regard the score beyond 50 as combined with depression,the score between 50-59 as mild depression,the score between 60-69 as moderate depression,the score over 70 as major depression;2 Detect blood lipid test?serum high sensitive C reactive protein?cortisol and soluble intercellular adhesion molecule-1 : detect blood lipid by enzyme reagent method,detect serum high sensitive C reactive protein by immune tubidmetric method,detect cortisol by chemilumin-escence method,detect soluble intercellular adhesion molecule-1 by enzyme linked immunosorbent assay.Results:1 Comparison of two groups basic data: Senior coronary heart disease patients combined with depression group and combined with non-depression group in sex,BMI,SBP,DBP,TG,TC,HDL-C and LDL-C,have no significant statistical(P> 0.05);2 Senior coronary heart disease patients combined with depression group serum hs-CRP,cortisol and sICAM-1 level(respectively 3.27±0.70 mg/L,24.1±6.4 ug/dL,303.5±61.0 ng/L)is significant higher than combined with non-depression group(respectively 1.30±0.20 mg/L,14.3±3.3 ug/dL,226.4±43.7 ng/L),the difference have significant statistical(P<0.01).3 According to coronary heart disease different lesion degree: Acute coronary syndrome combined with depression group serum hs-CRP?cortisol and sICAM-1 level(respectively 3.53±0.70 mg/L,26.0±6.3ug/dL,317.2±59.5ng/L)is higher than stable angina pectoris combined with depression group(respectively 2.97±0.57 mg/L,22.0±6.0ug/dL,287.8±59.8ng/L),the difference have significant statistical(P<0.05).4 According to coronary heart disease combined with different depression degree: Senior coronary heart disease combined with non-depression group serum hs-CRP,cortisol and sICAM-1 level respectively are(1.30±0.20 mg/L,14.3±3.3 ug/dL,226.4±43.7 ng/L),combined with mild-moderate depression group serum hs-CRP,cortisol and sICAM-1 level respectively are(3.11±0.64 mg/L,22.8±5.9 ug/dL,296.0±55.4 ng/L),combined with major depression group serum hs-CRP,cortisol and sICAM-1level respectively are(3.63±0.70 mg/L,27.1±6.7 ug/dL,320.7±70.7 ng/L),combined with mild-moderate depression group and combined with major depression group level are higher than combined with non-depression group(P<0.05),as depression degree is heavier,serum hs-CRP,cortisol and sICAM-1 level is higher.But comparison of group F with group E on sICAM-1 level has no significant statistical difference(P>0.05).5 There are significantly positive correlation between serum hs-CRP,cortisol and sICAM-1 level and depression score in group B(respectively r=0.791,P<0.01;r=0.623,P<0.01;r=0.482,P<0.01).Conclusion: The higher serum hs-CRP,cortisol and sICAM-1 level change in senior coronary heart disease patient combined with depression is,the higher depression score is,the heavier depression degree in senior coronary heart disease patient is.Detect the level change of serum hs-CRP,cortisol and sICAM-1 in senior coronary heart disease patient,play a important reference value on disease prognosis?treatment and prognosis.