Quality Even-5 Flavour Bolus Preliminary Study Of The Effects On Theliver

Mongolian medicine zhilian-5 tablet is provided by Career Technical College(Inner Mongolia Hulun Buir Mongolian medicine experts prescription),the clinical application of the drug for more than 30 years,and the curative effect in the treatment of drug-induced liver injury betterprescription,the drug induced acute liver injury protective effects on the experimental study of Mongolian medicine,further confirmed the clinical curative effect of the drug,and to explore its mechanism,to provide scientific data for its development and application.Firstly,drug-induced liver injury(drug-induced liver injury,DILI),literature review,comparative detail from modern medicine,traditional Chinese medicine,Mongolian medicine on DILI disease,diagnostic criteria,classification,etiology,pathogenesis,dialectical treatment,research status and so on.Secondly,Wistar rats were selected,the research zhilian-5 tablet protective effect on CCl4 and D-galactosamine induced drug induced liver injury,experimental results show that,the drug can reduce the content of rat serum ALT,AST,ASP and D-galactosamine induced by carbon tetrachloride liver injury;at the same time,inhibit the elevation of MDA in liver homogenate,improve liver homogenate SOD,GSH-Px;and reduce the liver index and hepatic steatosis,necrosis was significantly improved.Prompt,zhilian-5 tablet has a protective effect on druginduced liver injury.Study on protective effect and mechanism of zhilian-5 tablet for drug-induced liver injury induced by CCl4.The drug can reduce the content of serum ALT,AST,ASP of drug induced acute liver injury induced by CCl4;at the same time,inhibit the elevation of liver homogenate MDA,improve the liver homogenate SOD,GSH-Px;and reduce the liver index and hepatic steatosis,necrosis and obvious improvement.