The Clinical Study On The Treatment Of The Decoction Bushenhuoxueyangmo Combined With Clomifene On Patients With Kidney Deficiency And Blood Stasis Polycystic Ovary Syndrome Infertility

Objective: to observe the clinical curative of the effect of prescription bu shen huo xue yang mo combined with clomiphene in patients who were diagnosed of Polycystic Ovary Syndrome cased by kidney deficiency and blood stasis and evaluated the scientific validity of the prescription which could provide a good scientific basis for the clinical.Methods: collected 60 cases with anovulatory inferlility that were diagnosed polycystic ovary syndrome in out-patient consulting gynecologists of Ruikang Hospital Affiliated to Guangxi University of Chinese medicine,and divided the 60 cases randomly into treatment group(30 cases)and control group(30 cases)following the principles and methods of clinical randomized controlled trials.The treatment group were treated with prescription bu shen huo xue yang mo combined with clomiphene citrate,while the control group were treated with clomiphene citrate alone.One course of treatment included three monthes and all the patients were treated in one course.In the course of the treatment,the menstrual conditions,the improvement of tcm syndromes,ovulation rate,pregnancy rate,the endometrial thickness,endometrial type,uterine artery pulsatilty index(PI),uterine artery resistance index(RI)and and other related indexes on the day of human chorionic gonadotropin(HCG) were recorded.In the end,The therapeutic effect indexes were compared after treatment and contrasted between groups after treatment,using SPSS 18.0 statistical software to make statistical analysis.Results:1.The difference of the age,category of infertility,duration of infertility,hormonal readiness,the syndrome of traditional Chinese medicine were not significant between the two groups.2.The two groups all could improve the Chinese medicine clinical syndrome of kidney deficiency and blood stasis,such as the lower back tingling,sexual hypoactivityand so on.The curative effect of the treatment group was better than that of the control group,there was significant difference between the two groups(P<0.01).3.The state of endometrial receptivity: The endometrial thickness between the two groups was very statistically significant after treatment.The endometrial type A rate in the treatment group was higher than the other group(P <0.01).The uterine artery blood flow parameter(PI,RI)had been greatly improved,the difference between the two groups was significant.4.The comparison of the cycle ovulation rate and pregnancy rate in the two groups after treatment: the cycle ovulation rate of the treatment and control groups were 80.49% and 65.38%,the difference of the two groups was statistically significant by statistical analysis.The rate of the total pregnancy of the treatment group were 37.93%,as the other group were14.29%.The difference of the rate of total pregnancy the was statistically significant(P<0.05).5.The comparison of the two groups in total effective rate: the rate of the total effective of the treatment group was 89.65%,while the control group was 71.43%.The difference between the two groups was significant by statistic analysis(P<0.05).Conclusion:1.The prescription bu shen huo xue yang mo and clomiphen had better therapeutic effect on the kidney deficiency and blood stasis due to polycystic ovary syndrome.2.The prescription bu shen huo xue yang mo and clomiphen could effectively improve the clinical symptoms of polycystic ovary syndrome due to kidney deficiency and blood stasis.3.The prescription bu shen huo xue yang mo and clomiphen could increase the rate of ovulation of the polycystic ovary syndrome with kidney deficiency and blood stasis.4.The prescription bu shen huo xue yang mo and clomiphen could get distinct effect in improving the endometrial type,thickness and reduce the uterine artery blood flow resistance index and pulsation index.Therefore,they could improve the receptivity of endometrium and increase the rate of precnancy.