| Objective:The purpose of this study was to explore the virtual histology intravascular ultrasound (VH-IVUS) imaging to assess coronary plaque characteristics.Comparative analysis of two different severity of dyslipidemia plaque in patients with acute coronary syndrome (ACS) and stable angina (SA).By further invasive VH-IVUS examination discuss the imaging characteristics of patients with dyslipidemia coronary atherosclerosis plaque.Analysis of lipid levels and atherosclerotic plaque correlated.Prediction plaque nature, guidance, clinical practice.Methods:Choose 87 Hospitalized patients from Yijishan hospital affiliated directly to wannan medical college from July 2014 to December 2015, who all received CAG examination, diagnosed with coronary heart disease, need to use intravascular ultrasound-virtual histology (IVUS-VH)to examine the imaging.There were 60 males and 27 females,52 cases of acute coronary syndrome (acute coronary syndrome, ACS),35 patients with stable angina (stable angina, SA), diagnosis in accordance with 2002 ACC/AHA revised standard. Collect general patient's age, sex, history of hypertension, history of diabetes, smoking history, etc. and Total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), apolipoprotein B (APOB), lipoprotein a (LPa), apolipoprotein A1 (APOA1). Statistical analysis of the differences between the two groups TC, TG, HDL-C, LDL-C, APOA1, APOB, LP (a), LDL-C/HDL-C, APOB/AP0A1. Analysis of coronary plaque proportion of necrotic tissue and coronary plaque load rate correlation analysis. All data are used SPSS 19.0 software for data analysis, measurement data to meanąstandard deviation, count data with a ratio or rate between the two groups were compared using chi-square test, Pearson correlation analysis of risk factors were analyzed using linear correlation, P<0.05 was considered statistically significant.Results:1.Patients generally no significant difference; 2.ACS group NC and DC proportion significantly higher than SA group (t=2.309,2.597, P<0.05), FT and FF proportion significantly lower than SA group (P<0.05); 3.Between the two groups NC, DC, FT, FF, PB was statistically significant (P<0.05),4.Analysis of lipid levels between the two groups:TC, TG, HDL-C, LDL-C, APOA1, APOB, LP (a), LDL-C HDL-C, APOB/APOA1 statistically significant (P<0.05); 5. when the patient LP (a) concentration greater than 300mg/L, NC ratio was positively correlated (r= 0.449, P <0.05); when patients LP (a) concentration less than 300mg/L, NC proportion was no correlation (r=0.022, P=0.885); APOB/APOA1 are positively correlation with plaque load rate (r=0.317, p<0.01); APOB are positively correlation with plaque load rate (r=0.401, p<0.001); APOA1 are negative correlation with plaque load rate (r=-0.249, p<0.05), TC are positively correlation with plaque load rate (r=0.349, p =0.001), TG are positively correlation with plaque load rate (r=0.306, p<0.05), LDL-C are positively correlation with plaque load rate (r=0.543, p<0.001), LDL-C/ HDL-C are positively correlation with plaque load rate and NC (r=0.363,0.276 p <0.05).Conclusion:1. Serum HDL-C, APOA1 concentration is a negative correlation with plaque burden rate; 2. By VH-IVUS confirmed dyslipidemia is an independent risk factor for atherosclerotic plaques.3. LP-a plasma levels and the degree of coronary artery disease was significantly positively correlated; 4. LDL-C/HDL-C ratio and NC that is a positive correlation which can predict coronary plaque characteristics; 5.lipid levels and IVUS-VH plaque evaluation was a positive correlation. |
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