Clinical Observation On Gexiazhuyu Decoction Combined With TACE For The Treatment Of PLC And Meta-analysis And Evaluation Of Jianpi Huayu Therapy Combined With TACE

1Clinical observation on Gexiazhuyu decoction combined with TACE for the treatment of PLC1.1 Objective: Target at patients with PLC,observe the clinical effect of gexiazhuyu decoction combined with TACE for the treatment of PLC.1.2Methods: According to the include and exclude criteria,collecting cases in Hubei Provincial hospital of TCM during Jan.2013 to Jan.2016,a total of 50 cases treated by computer randomization were randomly divided into treatment group and control group(25:25).The control group were receiving TACE treatment alone,and the treatment group were receiving gexiazhuyu decoction one dose a day,30 days are on therapeutic course(3 in total).Observe the survival rate of the patients,short-term effect,tumor size,score of TCM clinical syndrome,ECOG score,the indicators such as tumor markers and liver function.Using IBM SPSS Statistics 19.0 software to analyze the data.1.3 Results:(1)The survival rate:The MST in treatment group was8.8 months;the MST in control group was 6.8 months;the half year survival rate of the treatment group was 92%;the half year survival rate of the control group was 84%;the treatment group are betterprolong the survival time than the control group;but there was no statistical difference between two groups after analyzing(P>0.05),(2)Short-term effect: Treatment group has an effect of 40% while the control group are 28%,there was no statistical difference between two groups after analyzing(P>0.05),however,the treatment group showed more improvement.(3)Tumor size: Both groups showed the tumor shrunk,but without statistical significance(P>0.05),however,the treatment group showed more improvement.(4)The improvement of clinical syndrome: The two groups after treatment of traditional Chinese medicine clinical symptom integral,the difference was statistically significant(P <0.05),treatment group was superior to control group in improving clinical symptoms.(5)The quality of life: Treatment group's quality of life period was 88%,the period of the control group was 68%,the more similar between the two groups have statistical significance(P < 0.05).Instructions in terms of improve the patients quality of life,the treatment group is better than the control group.(6)Tumor marker and liver function: Two groups after treatment of AFP and ALT,AST,ALB,propagated comparison,difference between groups was statistically significant(P < 0.05,P < 0.05),indicating in reducing AFP,improve liver function indicators,the treatment group is better than the control group,the treatment group had better effect on lowering AFP,improving the function of liver.1.4 Conclusion: This study shows that,compared with TACE treatment alone,combined with gexiazhuyu decoction had better effect on quality of life;Lowering the indicator such as tumor marker and improving function of liver.In prolonging survival time and improve the recent curative effect on improved,also have certain effect on the improvement of the lesions.2Meta-analysis and evaluation of Chinese medicine method of Jianpi Huayu therapy combined with TACE for the treatment of PLC2.1Object: Analysis and evaluation of the efficacy of Chinese medicine method of Jianpi Huayu therapy combined with TACE for the treatment of primary hepatic carcinoma,aims to provide reliable evidence for its clinical effect.2.2Methods: Search on Chinese databases including CNKI,WANFANG DATA and VIP,collecting all the literatures related to Chinese medicine method of Jianpi Huayu therapy combined with TACE for the treatment of primary hepatic carcinoma from 2011 to2015.Along with reviewing and organizing all the literatures,doing screening according to include and exclude criteria,and then make evaluations based on revised version of Jadad Scale;followed with meta-analysis of the variation and improvement rate of post-treatment effect(CR),patient life quality(KPS score),half-year survival rate and one-year survival rate using statistical software RevMan 5.22.3Results: In total,there are 10 Chinese papers about clinical randomized controlled trials meet the criteria,822 cases,417 were in treatment group and 405 were in control group.Jadad Scale showed that the literatures included were studies with poor quality.Among the ten literatures,7 of them compared the short-term effect(CR),Meta-analysis showed that OR=2.40(OR>1),95%CI[1.54,3.74],P=0.0001.which means the improvement rate of KPS score on treatment group is statistical significant was superior to that on control group;4 studies reported that the half –year survival rate of two groups,with Meta-analysis showed that OR=3.24(OR>1),95%CI[2.02,5.19],P<0.00001,which werestatistical significance,the treatment group was better than the control group;3 studies reported that the one year survival rate of two groups,with Meta-analysis showed that OR=3.35(OR>1),95%CI[1.75,6.42],P=0.0003,which were statistical significance,the treatment group was better than the control group;2.4Conclusion: Chinese medicine method of Jianpi Huayu therapy combined with TACE for the treatment of PLC has advantage on aspects such as improving the short-term effect of treatment of tumor,improving patients' quality of life,and the survival rate.