Three Skin External Use In The Prevention And Treatment Effect Of Radiation Dermatitis In Patients With Nasopharyngeal Carcinoma

Objective:Discussion 3 skin external use in radiotherapy in NPC patients dermatitis effects and topical drug costs based on this analysis, to be the best choice for the skin external use of radiotherapy in patients with nasopharyngeal carcinoma.Methods: This topic will be the time of admission in August 2014 to October 2015 in a three-level Cancer Hospital for treatment of nasopharyngeal cancer patients for the screening of the population, in strict accordance with pre-designed inclusion criteria,exclusion criteria and follow the voluntary participation In principle, a total of 120 cases included in the study. Using a random number table were randomly divided into three groups, namely, triethanolamine cream group, aloe gel group, radiation treatment of skin protectants(Li Funing) group. In addition to the three groups studied different skin external use, other conditions remained relatively consistent, such as:health education, nutritional support, radiation dose, concurrent chemotherapy programs. During radiation therapy by trained professionals to study the radiation field of local circumstances, a detailed record of chemotherapy programs and case report forms before the logbook radioepidermitis research developed through literature and consult the department combined the actual situation. Among them, the assessment of radiation dermatitis, using the RTOG scale American Radiation Therapy Oncology Group widespread international use; partial radiation field for pain assessment, the use of the broad international general digital pain score table; for radioepidermitis assessment area, the use of the tape by the investigator unified purchase, each tape error <0.1cm. The researchers collected data on a regular basis,aggregate and will double check and correct the data recorded in the Chinese version of Excel 2007, and in the three groups after radiotherapy in patients with levels of radiation dermatitis during radiotherapy, radiation dermatitis occurrence area, localradiation field feel pain score, complete topical entire cost of radiotherapy and radiation dose data couples for the first time when radiation dermatitis occurs after verification entry SPSS21.0 to analyze, for pairwise comparison of data between multiple sets of rank, should be adopted nonparametric rank sum test of Kruskal-Waillis H test, at the basic of this static to use Nemenyi test to comparation.Results: Outside the three skin treatment in the clinical application process, no adverse reactions, and in patients with nasopharyngeal carcinoma effect in both prevention and treatment of radiation dermatitis.Three groups of 100% radiation dermatitis occurs, but occurs at different levels. Triethanolamine cream efficacy lies mainly in delaying the occurrence and prevention of radiation dermatitis and dry change, but there are still local absorption slow drug neck skin scabs fall off hard and difficult to clean patients' subjective and objective factors such as local feel comfort poor, and expensive, not easy to accept patients. Aloe vera gel in the prevention and treatment of NPC patients radiodermatitis can effectively delay the onset and reduce the incidence level radiation field feel local pain, and inexpensive, can reduce the financial burden of patients to some extent, but not reduce radiation dermatitis and expand its area. Li Ning skin as triethanolamine and aloe mixture, having the single drug incomparable superiority. In effect, not only benefit the skin rather significantly delayed in patients with nasopharyngeal carcinoma radiation dermatitis occurs,deterioration and reduce the level of radiation dermatitis occurs, to avoid the spread of radiation dermatitis area, the radiation field can effectively relieve local pain experience. In terms of price, benefits Funing price ranking among triethanolamine cream and aloe vera gel, easy to patients. 3 group difference was statistically significant(P<0.05). Among the three groups was statistically significant pairwise comparison, Triethanolamine cream group and aloe vera gel group difference was statistically significant pain( ?2=9.62,P < 0.05), Aloe vera gel is better than triethanolamine cream can be more effective in relieving pain localized radiation field,However, radiation dermatitis grade, size and radiation dose radiation dermatitis occurs the first time the difference was not statistically significant( P > 0.05);Triethanolamine cream group and interest groups rather painful skin only difference was not statistically significant(?2=2.47,P>0.05),The rest of the observed indicators were statistically significant(P<0.05),Lee skin cream rather than triethanolamine,to better mitigate and delay the occurrence and deterioration of radiation dermatitis,radiation dermatitis avoid the expansion of the area; Aloe vera gel and group profit Funing group only in terms of classification of radioactive dermatitis statistically significant difference(?2=6.32,P<0.05),Li Ning skin than aloe vera gel, Li Ning is more conducive to lighten skin and delay the occurrence of radiation dermatitis,The rest of the parameters were not statistically significant difference was observed(P>0.05). Conclusion: Li Ning skin as triethanolamine and aloe mixture, in terms of the efficacy of radiotherapy in NPC patients dermatitis, with a single drug incomparable superiority, and affordable, easy to patients, is worthy of clinical application.