Clinical Study On The Relationship Between TCM Syndromes Of Unstable Angina Pectoris And Cardiac Troponin I, Cystatin C, Lipoprotein(a)

Objective: To approach the relationship between Cardiac Troponin I, Cystatin C,Lipoprotein(a) and TCM-Syndrome Differentiation type of Unstable Angina Pectoris,and provide theoretical basis for TCM-Syndrome Differentiation type of Unstable Angina Pectoris.Methods: 172 patients with Unstable Angina Pectoris are collected according to diagnostic criteria and divided into five groups: heart blood stasis syndrome group(47simples), phlegm and turbid resistance syndrome group(42 simples), stagnation of yin-cold syndrome group(31 simples), deficiency of both qi and yin syndrome group(27 simples), heart and kidney yang deficiency syndrome group(25 simples). Control group had 30 healthy subjects. All the members' plasma are collected to detect the levels of c Tn I, Cys C, Lp(a). All the patients are classified into several standard according Braunwald and record the data.Results:1. The number of patients with heart blood stasis syndrome and phlegm and turbid resistance syndrome is more than patients with other syndromes, and the proportion of these two syndromes in all patients account for 51.7%.The patients with heart and kidney yang deficiency were older than other patients, and the disease course are longer than other patients.2.The level of cTnI in patients with heart blood stasis is obvious higher than level of control group and other patients, and the difference is statistically significant(P < 0.05). The level of Cys C in patients with heart blood stasis and patients with phlegm and turbid resistance is higher than level of control group and other patients, and the difference is statistically significant(P < 0.05). The level of Lp(a) in patients with phlegm and turbid resistance is higher than level of control group and other patients, and the difference wis statistically significant(P<0.05).3.The grade distribution of Braunwald among all the group is statistically significant. The average rank sum of patients with heart blood stasis syndrome is highest. Though the comparison of grade distribution of patients with excessive syndrome(heart blood stasis syndrome, phlegm and turbid resistance syndrome and stagnation of yin-cold syndrome) and patients with deficiency-syndrome(deficiency of both qi and yin syndrome and heart and kidney yang deficiency syndrome), we can find the difference is statistically significant(P<0.05).4.The level of Cys C in patients with different grade of Braunwald is different,and the difference is statistically significant(P<0.05). The level of Lp(a) in patients with different grade of Braunwald is different, and the difference is statistically significant(P<0.01).Conclusion:1. Patients with heart blood stasis syndrome and phlegm and turbid resistance syndrome are accounted for the most in the patients of Unstable Angina Pectoris. The results show that blood stasis and phlegm turbidity play an important role in etiology and pathogenesis of traditional Chinese medicine in Unstable Angina Pectoris.2.Patients with heart and kidney yang deficiency syndrome are older than other patients and their disease course are longer than other patients. These investigations suggest that age, course of diseases can be taken as reference to heart and kidney yang deficiency syndrome differentiation factors in patients with Unstable Angina Pectoris.3.The level of cTnI is closely related to heart blood stasis syndrome of Unstable Angina Pectoris, so it can be used as the basis of syndrome differentiation of heart blood stasis syndrome in patients with Unstable Angina Pectoris. The level of Cys C is closely related to heart blood stasis syndrome and phlegm and turbid resistance syndrome of Unstable Angina Pectoris, so it can be used as the basis of syndrome differentiation of these two syndrome in patients with Unstable Angina Pectoris. The level of Lp(a) is closely related to phlegm and turbid resistance syndrome of Unstable Angina Pectoris, so it can be used as the basis of syndrome differentiation of phlegm and turbid resistance syndrome in patients with Unstable Angina Pectoris.4. Braunwald classification has relationship with excessive and deficient TCM syndrome differentiation of Unstable Angina Pectoris, and it reflects the severity of Unstable Angina Pectoris among patients with different syndrome of TCM.5. Braunwald classification has relationship with the level of Cys C and Lp(a),and the increased level of Cys C and Lp(a) suggest that the condition of patients with Unstable Angina Pectoris is worsen.