Development Of Control And Management System For Rapid Platelet Function Analysis With Multi Modes

Platelet is a vital component of blood cell, and the rapid analysis of its coagulation and aggregation function is quite important for accurate treatment and diagnosis of thrombosis, antiplatelet drug efficiency detection. To meet the requirements such as with more assay modes, higher efficiency and better user experience based on the basic analyzer, the development of a new kind of control and management system for rapid platelet function analysis with multi-mode is presented in this dissertation.The system is composed of control module and management module, and they communicate with each other through SPI interface. The control module takes charge of signal detection, assay process control and so forth. The management module is responsible for assay modes management, human-machine interaction, instrument maintenance and some other tasks. The system can analysis platelet function affected by particular reagent by controlling the assay parameters (temperature, reagent concentrations, etc.) and several times of assay process which contains adding blood sample, dilution, adding reagent, counting and cleaning. The controlling software and management software are developed based on the basic system. By optimizing assay process and adding the management function for roulti assay modes, the new system can improve assay efficiency and increase types of assay modes. Based on this, new proposal of paralleling control modules is proposed. Reliable communication is designed and the structure of management software is changed for this proposal which improve the efficiency greatly.Firstly, the significance and current development of platelet function analysis are introduced, and the requirements of the new analyzer are given. To meet these requirements, the basic system is optimized by optimizing assay process and paralleling control modules respectively. After introducing the principle of controlling software for optimizing the assay process, some software modules, which are assay process control, motor parameters design and assay results process are developed. The development of important software modules of the management software for optimizing the assay process such as management of multi assay modes, data management and upload, are given in dissertation. To improve the efficiency further, the proposal of paralleling the control modules are proposed. SPI interface is redesigned for the communication between one management module and multi control modules, key technologies to realize this proposal from both hardware and software aspects are described, and management software structure are given for controlling multi assay channels. The system developed in this dissertation is directed used in two kind of platelet function analyzer. In the end, the performance evaluation of the system from repeatability, efficiency, and operability aspects are conducted, validating the applicability, rationality and correctness of assay result of the control and management system.