The Effect Of The Flavored Buzhongyiqi Decoction On Clinical Curative And Humoral Immune Factors In Patients With Myasthenia Gravis

Objective:1. This study was to observe the flavored Buzhongyiqi decoction on spleen kidney both deficiency type myasthenia gravis patients clinical curative effect, and verify the effectiveness of the flavored Buzhongyiqi decoction for the treatment of myasthenia gravis.2. Observe the flavored Buzhongyiqi decoction treatment of myasthenia gravis patients with humoral immune index AchRAb level change, and to analyze its possible mechanism of effect.Methods:Selection in henan college of traditional Chinese medicine the first affiliated hospital outpatient and ward patients with myasthenia gravis (?,?) 40 cases, in line with the "impotent" disease of TCM diagnosis, syndrome differentiation for "spleen kidney both deficiency type", would be consistent with diagnostic criteria according to random number table method of 40 patients were divided into two groups:control group 20 cases, treatment group (20 cases, control group of 20 cases with bromine overlooks the Ming:60 mg/time,3 times/day, the treatment group of 20 patients with bromine overlooks if Ming yiqi decoction soup flavored filling, daily 1 agent, two suit, a course of 12 weeks. Records of two groups of patients with myasthenia gravis clinical absolute scores before and after treatment, clinical relative score and TCM symptoms integral and humoral immune index AchRAb level changes, the result of the two groups of treatment data using SPSS18.0 statistical software and EXCEL software for statistical analysis.Results:1. The treatment group and control group after treatment, the clinical total effective rate of treatment group is higher than the control group, the clinical total effective rate of the difference was statistically significant (P<0.05). add the flavored Buzhongyiqi decoction in the treatment group therapy effect is better than that of unused the flavored Buzhongyiqi decoction of the control group; Two groups of clinical absolute scores points down, compared with before treatment were and are significant difference compared with before treatment (P<0.05),shows that after treatment with different methods,clinical symptoms were improved significantly in the two groups of patients, two groups of patients after treatment of the clinical absolute scores by statistical analysis (P<0.05), add the flavored Buzhongyiqi decoction in the treatment of patients is better than unused the flavored Buzhongyiqi decoction of patients.2. The treatment group and control group after treatment of TCM syndrome score was has the drop, with significant difference (P<0.01), the clinical symptoms of two groups of patients with myasthenia gravis were improved. Treatment group and control group patients after treatment of the TCM syndrome score by statistical analysis (P< 0.01),Add the flavored Buzhongyiqi decoction in the treatment group in improving clinical absolute scores significantly superior to not use the flavored Buzhongyiqi decoction in the control group.3. The control group and treatment group after treatment the humoral immune index acetylcholine receptor antibody (AchR-Ab) levels compared with before treatment, significant differences (P< 0.05); Treatment group after treatment the humoral immune index AchRAb level changes significantly, compared with the control group, significant differences (P< 0.05). Compared with the control group, treatment group found no obvious adverse reaction, the security is higher.Conclusion:1. Use the flavored Buzhongyiqi decoction+foundation treatment of bromine and overlooks (Ming) treatment of spleen kidney both deficiency type myasthenia gravis patients, clinical symptoms change and TCM syndrome is superior to use bromine overlooks Ming of the patients, and the flavored Buzhongyiqi decoction in the treatment group compared with control group found no obvious adverse reaction, the security is higher.2. After treatment, the treatment group and control group acetylcholine receptor antibody in serum (AchR-Ab) all have varying degrees of decline, while the treatment group compared with control group, the degree of decline is more apparent, flavored filling is illustrated in yiqi decoction for the treatment of myasthenia gravis patients may be effective mechanism, by regulating the body's immune system, in turn, reduce the generation of acetylcholine receptor antibody, restore the function of neuromuscular junction acetylcholine receptors, eventually improve the symptoms of patients with muscle weakness.