Lung Tumor Extract In Mice With Lewis Lung Cancer With Qi Stagnation Syndrome Of Qi Deficiency And Intervention Model In Patients With Lung Cancer Chemotherapy Effect

Objective: The reliability test through the experimental study of qi stagnation type Lewis disease tied mice lung cancer was established with the model, and to observe the intervention effect of anti lung tumor cream for qi stagnation type of lung cancer, curative effect evaluation of lung tumor ointment in the treatment of non-small cell lung cancer. At the same time, 77 cases of advanced non-small cell lung cancer patients by clinical observation, the improvement of clinical curative effect observation of chemotherapy combined with lung qi deficiency symptoms and anti tumor ointment in the treatment of non-small cell lung cancer.Methods: 1 by bundling method to establish the animal model of qi stagnation constitution, based on the ATCH performance and blood index in mice observed, reliability of qi stagnation type lung cancer animal model to determine the establishment of the evaluation. 2 through the observation of lung tumor suppression treatment cream and the control of gentleness and reagent stagnation of lung cancer mice model. Determination of tumor volume change, tumor growth rate, the rate of lung metastasis, blood rheology and ATCH. 3 observation of lung qi deficiency type of tumor suppression advanced ointment on 77 cases of lung cancer and improve the symptoms of qi deficiency in patients with non-small cell lung cancer, clinical value evaluation of pulmonary tumor extract on non-small cell lung cancer with Qi deficiency symptoms.Results: 1 give two treatment group lung tumor extract in limiting Lewis lung cancer lung metastasis could play a different effect. Body weight, serum ATCH and the number of the gentleness group mice were significantly lower compared, and significant(P < 0.05). 2 groups of mice appear listlessness had different degrees of tumor, hair thinning, reduced activity, reduced the phenomenon of diet. The QD group was the most significant. PZ, QZ and normal activities of spirit. 3 did not give Qi Fei Yiliu cream gavage control group(QD) and the level and quality control group(PD) in Lewis mice transplanted tumor volume, tumor volume, improve the quality of tumor growth rate and tumor spread / limit rate, VEGF-C there is no difference between the light intensity aspects(P > 0.05). The experimental group was given 4 lung tumor extract plays a different role in the growth of Lewis lung cancer xenografts. The gentleness group and qi stagnation group the inhibition rates were 31.38%, 30.27%, with the single factor variance was found in the control group the lung tumor extract group corresponding to small, the difference was significant(P < 0.05). 5 the gentleness group limited lung metastasis rate is 22.76%, qi stagnation group is 33.13%, single factor variance analysis showed that the lung tumor extract group than the corresponding control group decreased, the difference was significant(P < 0.05). 6 in the change of blood rheology, lung tumor paste treatment group compared with non treatment group corresponding to the P is less than 0.05, with significant difference. The gentleness group and qi stagnation group, P < 0.05, with significant difference. Qi stagnation of lung tumor and Lung Ping Ointment group and tumor cream group, P > 0.05, does not have the difference. 7 give two treatment group lung tumor extract different in inhibiting the expression of VEGF-C was. The gentleness group and qi stagnation group the average optical density of VEGF-C were(0.131 + 0.039),(0.145 + 0.015), single factor variance analysis showed that the lung tumor extract group than the corresponding control group decreased, the difference was significant(P < 0.05). The symptoms and signs of 8 patients with non small cell lung cancer of qi deficiency syndrome score can be found that chemotherapy can aggravate the degree of qi deficiency patients, Chinese medicine combined with chemotherapy group and chemotherapy group, the difference scores before chemotherapy and after chemotherapy had significant difference(P < 0.05), that can relieve the symptoms of qi deficiency patients.Conclusion: Symptoms of qi stagnation type of lung cancer in mice to establish 1 binding method combined model reliability and different Yu Ping and mice, this model method to establish the animal model of qi stagnation syndrome has significance. There was no significant difference between the 2 qi stagnation group Lewis mice with the gentleness group in the growth and metastasis of lung cancer. 3 lung tumor extract for Lewis lung tumor growth and metastasis inhibition. Qi 4 lung tumor ointment can improve qi stagnation syndrome of lung cancer model. 5 lung tumor extract may inhibit the expression of VEGF and play a role in the treatment of advanced lung adenocarcinoma. 6 lung tumor extract can improve lung cancer patients with Qi deficiency and Qi deficiency symptoms. 7 patients with chemotherapy can aggravate the symptoms of Qi deficiency.