Association Between Plasma Fibrinogen And Metabolic Abnormalities In Essential Hypertension

Objective: The aim of this study was to investigate the relationship between plasma fibrinogen(Fib)and metabolic abnormalities in essential hypertension(EH)patients.Subjects and methods: A total of 966 EH patients were enrolled and 77 subjects without any MS component were selected as control group from the First Affiliated Hospital Fujian Medical University between August 2000 to May 2015. MS was defined based on the 2004 definition of Chinese Diabetes Society. The EH patients were divided into MS group(n=546) and NMS group(n=420). Meanwhile patients were divided into four groups according to the numbers of metabolic risk factors(central obesity, hyperglycemia and hyperlipidemia): EH without metabolic risk factor、EH with one、two、three metabolic risk factors. Plasma Fibrinogen level was compared among groups.Results: 1 、 The plasma Fib concentrations and the percentages of hyperfibrinogenemia increased gradually among control group、NMS group and MS group(2.83±0.59 vs 3.18±1.10 vs 3.35±1.00, P<0.01; 3.39% vs 13.19% vs 20.71%, P<0.05).Further subgroups analysis revealed that the plasma Fib concentrations and the ratio of hyperfibrinogenemia in EH+1/EH+2/EH+3 group were significant higher than the control group and EH+0 group(3.22±0.93、3.31±0.97、3.49±1.09 vs2.83±0.59 vs 2.97±0.71, P<0.05; 15.91%、19.94%、23.08% vs 3.9%vs8.24%, P<0.05). 2、In EH patients, Pearson correlation analysis indicated that the plasma fib levels were positively related with the age、SBP、FBG、WBC counts、Total bilirubin and IVST(P<0.05). 3、Logistic regression analysis revealed that after adjusting for gender、age、smoking, MS was associated with 4.587-fold(95%CI 1.377-15.286,P<0.05)、1.629-fold(95%CI 1.149-2.308,P<0.01)odds of having hyperfibrinogenemia compared with the control and the NMS subjects respectively. EH subjects with 1、2 and 3 metabolic risk factors were associated with 3.434-fold(95%CI 1.020-11.564,P<0.05)、4.332-fold(95%CI 1.287-14.581,P<0.05)、5.363-fold(95%CI 1.405-20.470,P<0.05)odds of having hyperfibrinogemia compared with the control group, 1.860- fold(95%CI,1.026-3.373,P<0.05)、2.402-fold(95%CI 1.330-4.338,P<0.01)、2.865-fold(95%CI 1.405-5.786,P<0.05)compared with the EH+0 group.Further adjusting for BP value,the risk of hyperfibrinogenemia in MS group was 1.533-fold higher than the NMS group(95% CI 1.071-2.195,P<0.05). 4、Logistic regression analysis revealed that after adjusting for gender、age、FBG、TG、DBP、UA,EH patients with hyperfibrinogenemia was associated with 1.507-fold(95% CI 1.023-2.218,P<0.05)odds of having metabolic syndrome compared with the EH patients without hyperfibrinogenemia.Conclusions: Plasma fibrinogen concentrations and the percentages of hyperfibrinogenemia significantly increase in essential hypertension with metabolic syndrome.Fibs are positively correlated with the numbers of the components of MS.