Study Of Heart Rate Variability In Patients With Coronary Heart Disease And Depression Disorder

Objective To study the changes of heart rate variability in patients with coronary heart disease and depression disorder, and clarify the changes of autonomic nerve function and guide the clinical therapy.Methods One hundred and twenty patients with coronary heart disease(40 cases),depression disorder(40 cases),both coronary heart disease and depression disorder(40 cases) and 40 cases of adult health as the control group were enrolled from December 2014 to December 2015 in our hospital. All patients were performed with electrocardiogram, echocardiography and ambulatory electrocardiography. The changes of heart rate variability were recorded using ambulatory electrocardiography. The time domain indexs of heart rate variability included SDNN、r MSSD、p NN50,and include LF、HF were the frequency domain indexs.Results Compared with control group,the time domain indexs of SDNN、r MSSD、p NN50 and frequency domain of LF、HF of heart rate variability decreased significantly in coronary heart disease group,depression disorders group and coronary heart disease with depression disorders group. In CHD with depression disorders group, the time domain indexs of SDNN、r MSSD、p NN50 and frequency domain indexs of LF、HF decreased compared with coronary heart disease group and depression disorders group, which was statistical significance(p <0.05).Conclusions The HRV decreased of CHD patients and depression disorder patients indicated that the automomin nerve function was demaged and disorder. The HRV of patients with both coronary heart disease and depression disorders were significantly decreased compared with coronary heart disease or depression disorder, the automomic nerve function was lower and more serious. This indicates that the occurrence of depressive disorder aggravated damage and functional disorder of the autonomic nerve, the risk of cardiovascular events more.