| Objective Analyzing change of AB drug resistance and infection distributio-n retrospectively during 5 years to provide reasonable and effective clinical appli-cations scheme of antibiotics treatment and control infection while delaying the development of Acinetobacter baumannii drug resistance or multidrug resistance.Methods From Jan 2010 to Dec 2014, the whole clinical data of 162 patients with AB infections in Department of Burn and plastic surgery were analyzed, the drug resistance and the characteristics of the infections were summarized.Results The detection rate of AB in burn ward was high. The result of 162 AB infection detected specimens was as following: there were 116(71.6%) strains isolated from the wound secretions, 25(15.4%) strains from sputum,16(9.9%) strains from blood, 5(3.1%) strains from deep intravenous cathete, no AB strain was isolated from feces or urine. AB still maintains a relatively high sensitivity(98.3%) to polymyxin B, the drug resistance rates with imipenem and minocycline were increasing in recent years, respective sensitivity from 50% fell to 28%, 75% to 35.3%, AB had nearly 100% resistance rate to the second and third generation cephalosporins with other 6 kinds of antibiotics, serious extensive drug resistant phenomenon.Conclusion The detection rate of Acinetobacter baumannii in burn ward is high, the distribution is widespread. drug resistance is serious, and a large part of the antibiotic resistance rate is rising year by year, the treatment of drugs is extremely limited, Polymyxin B is still the preferred drug for treatment of Acinetobacter.Monitoring changes in the drug-resistant strains and development of Acinetobacter baumannii closely, pinning hope on a new antibiotic research and development, at the same time strengthen the supervision of antibiotics, give priority to prevention, strengthen hospital infection control and AB diagnosis and treatment, preventing or delaying the increase of AB drug resistance rate or decrease infection. |
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