Influence Factors Analysis And Prevention Strategies Of Intracranial Infection After Pituitary Tumor Resection By Transnasal Transsphenoidal Approach

Objective Pituitary Tumor is one of the most common tumors in the saddle area. The character of the tumor is benign.Surgical treatment is the preferred method for the treatment of pituitary adenomas in addition to pituitary prolactinomas.The development and progress of the micro Department of Neurosurgery makes the clinical application of the surgical resection of pituitary tumor by endoscopic and microscopic approach become more and more extensive.The vast majority of the tumors can be removed via a nasal dish approach.The most of the tumors can be removed via transnasal transsphenoidal approach.One of the complications of surgery is intracranial infection which increases the suffering of patients,prolong the treatment time and increases the cost.And it can cause serious consequences and even endanger life if can not be timely and effective prevention and treatment. This study aims to analysis the factors which can cause intracranial infection after transsphenoidal pituitary tumor resection in neurosurgery department of our hospital,So it can provide a certain basis for the prevention and treatment of postoperative intracranial infection and reduce the incidence of it.Methods The data of patients with pituitary tumor who underwent the operation via transnasal transsphenoidal approach from October 2015 to January 2010 In our hospital were retrospectively analyzed. Recorded data included in the patient's basic information(gender, age), intraoperative saddle septal damage, intraoperative bleeding volume, postoperative cerebrospinal fluid leakage, postoperative indwelling drainage tube, operative time, postoperative hospitalization time, pulmonary infection, reoperation, surgical approach and past medical history(diabetes mellitus, hypertension).First, the collected data were assigned to the data and then the every factor was analyzed by chi square test(single factor analysis) by using SPSS21.0 software package.The factors which are involved with the topic and have statistical significance(P<0.05) will be selected out,and then these factors were analyzed by Logistics regression(multivariate analysis).Finally we find the related factors of intracranial infection after the operation, and then assess of the relationship between the factors and postoperative intracranial infection according to the relative risk, and then provide some reference value for clinical prevention and treatment.Results The total number of cases collected in this study was 319. There were 12 cases of postoperative intracranial infection, the infection rate was 3.76%.The results of chi square test showed that P value of postoperative indwelling drainage tube,postoperative hospital stay, pulmonary infection and postoperative cerebrospinal fluid leakage were less than 0.05, and the difference was statistically significant.It can be considered that the four are risk factors of postoperative intracranial infection.The results of Logistic regression analysis showed that the postoperative indwelling drainage tube was the highest risk factor for postoperative pituitary tumor surgery, and the postoperative hospital stay, pulmonary infection and postoperative cerebrospinal fluid leakage were risk factors.Conclusion 1.Conclusions:The study found that the risk factors of postoperative intracranial infection in patients who resected pituitary tumor by transnasal transsphenoidal approach included: postoperative indwelling drainage tube, postoperative hospital stay, pulmonary infection and postoperative cerebrospinal fluid leakage. The highest risk of them is postoperative indwelling drainage tube,and then followed by postoperative hospital stay, pulmonary infection and postoperative cerebrospinal fluid leakage.2.The influence factors of intracranial infection after pituitary tumor resection by transnasal transsphenoidal approach are many, and each factor can influence each other.3.In view of the above four independent risk factors, the active prevention and treatment can effectively reduce the incidence of postoperative intracranial infection and have better recovery after the pituitary tumor resection.