The Study On Correlation Between Hyperuricemia And The Laboratory Tests Of Kidney Injury

Objective: To investigate the prevalence of hyperuricemia and the knowledge degree of hyperuricemia-induced kidney impairment in Ma’anshan.Additionally,to probe the value of serum cystatin cystatin C(Cys C),β2-microglobulin(β2-MG)in the early diagnosis of hyperuricemia-induced kidney impairment.Methods: We retrospectively studied and calculated the prevalence of hyperuricemia in Ma’anshan by collecting 25,666 people who received physical healthy examinations in physical examination center from July 2015 to June 2016.We also collected a total of98 patients(outpatient or inpatient)in Ma’anshan city people’s hospital from March2016 to May 2016 to analyze and evaluate the correlation between glomerular filtration rate(GFR)and serum cystatin C based on the level of GFR,serum cystatin C,creatinine,uric acid and other variables.With the use of epidemiological investigation,we performed questionnaire survey on a total of 100 cases from the hyperuricemia group and the control group,the content including smoking,drinking,dietary structure,the knowledge degree of hyperuricemia-induced kidney impairment as well as exercise.We performed a association study to compare the hyperuricemia group(including 50 patients with gout diagnosed in Ma’anshan city people’s hospital)and the control group(including 50 healthy cases without diabetes,cancer,recent urinary tract infection and kidney diseases)in terms of urine β2 microglobulin,serum cystatin C,creatinine,uric acid,urine PH,specific gravity and other laboratory tests.We used t-test to analyze if there were statistically significance among patients with gout>5 years,≤5 years and the control group.Subsequently,the Logistic regression analysis was carried out usingcystatin C and urine β2 microglobulin as the dependent variables,and blood pressure,blood glucose,alcohol consumption,blood uric acid,age,sex as independent variables.The data was analyzed by using SPSS16.0 software and P<0.05 was considered statistically significant.We used t-test for sample mean comparison between two groups and chi-square test for sample percentage comparison.Results: The prevalence of hyperuricemia in male in Ma’anshan was 12.75% versus4.99% in female.The knowledge degree was lower in patient group than in control group.The level of serum cystatin C had a significant difference between patients in CKD1 and CKD2 period;no statistical difference was found in terms of creatinine and uric acid.The Kappa values of serum cystatin C,creatinine,uric acid values were 0.471,0.056 and 0.137,respectively.No statistical difference was found in terms of age,sex and urine PH between the hyperuricemia group and the control group.Significant difference was found between two groups in terms of blood cystatin C,urinary β2microglobulin,alcohol consumption,lipoprotein-a,hemoglobin,blood carbon dioxide binding force,urine red blood cell count,urinary specific gravity and blood pressure.Significant difference was found in terms of blood cystatin C,urinary β2 microglobulin between the control group and the group of gout≤5 years.Similarly,significant difference was found in terms of blood cystatin C,urinary β2 microglobulin between the group of gout≤5 years and the group of gout >5 years.By using serum Cystatin C as dependent variable,logistic regression analysis results showed that blood uric acid(OR=98.00,95%CI:24.631-389.909)was related to serum Cystatin C;By using urinaryβ2 microglobulin as dependent variable,logistic regression analysis results showed that blood uric acid(OR=8.14,95%CI:2.858-23.202)was related to urinary β2microglobulin.Conclusion: The prevalence of hyperuricemia in male is higher than that in female in Ma’anshan.Hyperuricemia is an independent risk factor for renal dysfunction.Theserum cystatin C,β2 microglobulinas has an important role in the early detection and diagnosis of gouty nephropaty,which is valuable for clinical application in the future.The indicators in urinary sediment such as red blood cells,crystal,white blood cells,blood lipid content,specific gravity,blood CO2-CP,hemoglobin and so on,which can play an auxiliary diagnostic role for renal injury caused by hyperuricemia.