The Correlation Between Lymphocyte Subsets Or Natural Killer Cells And Parkinson's Disease In Uygur And Han

Objective:To study the variation and clinical significance of lymphocyte subsets and natural killer(NK)cells in Parkinson's disease(PD).Methods:Flow cytometry was used to measure the numbers of T lymphocytes,B lymphocytes and NK cells in the peripheral blood of total 33 Han and Uygur PD patients.Then we compared the results with 20 healthy controls.Results:Compared with healthy controls,the numbers of CD3+,CD4+,CD8+ significantly decreased.The decrement of CD19+ had no statistic significance.The CD56+ increased significantly.There was no significant change in the number of lymphocyte subsets and NK cells in Uygur patients compared with Han patients.When the patients accepted the treatment of L-dopa or Pramipexole,no signifiant differences of subsets were observed.There was a significant linear correlation between age and CD3+ subsets,duration and CD19+ subsets.Conclusion:Lymphocyte subsets and NK cells changed in the peripheral blood of PD patients,which demonstrated the immune disorders in the pathogenesis of PD.However,there were no changes between Han and Uygur groups.The changes of Lymphocytes and NK cells may help assess the severity of PD.