The Prognostic Value Of Ki-67,P16 And CK34βE12 Protein In Surgical Cervical Cancer

Objective:Discussion the prognostic value of Ki-67,P16,CK34βE12 antigen,pathological features and postoperative adjuvant treatment on the operable cervical cancer patients.Methods:The expression of Ki-67、P16、CK34βE12 in 72 cases of postoperative Cervical Carcinoma was detected by immunohistochemistry to follow up the PFS,Combining with pathological features and treatment of patients,ending with the progression of disease.Univariates were analyzed by Kaplan—Meier method,Multiple factors were analyzed by Cox regression analysis.Results: Univariate analysis showed :ki-67(p = 0.006),CK34βE12(p = 0.007),the production situation(p = 0.018),menopausal status(p = 0.008),national(p = 0.034),pain situation(p = 0.008),tumor FIGO stage(p = 0.000),tumor size(p = 0.015),lymph node metastasis(p = 0.000),and chemotherapy(p = 0.016)related to the patients prognosis.Cox multivariate analysis showed: the expression of ki-67,age,maternity,menopausal status,degree of differentiation、depth of myometrial invasion、violations along the uterus,radiotherapy can effect the PFS(P <O.05).However,the expression of P16 and CK34βE12 patient antigen,tumor size,age at menarche,nationality,occupation,surgery and chemotherapy have no significant effect on PFS(P> O.05),not yet as an independent prognostic factor.Conclusion:Ki-67 high expression,young,premature delivery,late tumor stage,deep grass roots and violations along the uterus,and the radiotherapy are the independent prognostic factors of cervical cancer.Expression of P16 and CK34βE12 antigens,tumor size,degree of differentiation,age at menarche,nationality,occupation,surgery and chemotherapy relate to the prognosis only,not yet as an independent prognostic factor.