| Purpose:To observe the clinical efficacy,long-term efficacy and safety of He Wei Yu Wei decoction treating Liver-Stomach Heat type chronic atrophic gastritis(CAG),and to provide a theoretical and clinical basis for the feasibility of the treatment of CAG.Method:1.Selection of October 2014-October 2016 in Hubei Province,Chinese medicine hospital spleen and stomach clinic outpatient clinic,are in line with CAG diagnostic criteria for Western medicine,and dialectical for liver and stomach heat 72 cases of patients with the study.Patients were randomly divided into experimental group and control group of 36 cases(Two cases of each fall off in 1 case,35 cases were involved in statistics).There were no significant differences in sex,age,course of disease,illness and syndrome scores between the two groups before treatment(P>0.05),comparable.2.The experimental group and the treatment of stomach worsening soup,a day,fry 300 ml,2 times sooner or later warm clothes.The control group was treated with Weifuchun Tablets,4 tablets/time,3 times/day,after meals Both groups were treated continuously for 12 weeks.Every two weeks referral once,record the symptoms,signs of change.Two groups of patients before and after treatment for a gastroscopy(requiring pathology)and safety indicators.3.Reference to "chronic atrophic gastritis diagnosis and treatment of traditional Chinese medicine opinion" and "gastrointestinal disease symptoms of traditional Chinese medicine" to establish the primary and secondary criteria and grading quantification score.The primary and secondary symptoms were evaluated before and after treatment.12 weeks after the review of endoscopy and pathology,and follow-up recurrence on time.4.The data recorded by SPSS21.0 statistical software for analysis,measurement data with t test,count data with X2 test,rank data with rank sum test.Result:1.Syndrome effect The control group: clinical recovery in 2 cases,markedly effective in 10 cases,effective in 11 cases,ineffective in 12 cases,the total effective rate of 65.71%.There was significant difference between the two groups(P <0.05),indicating that the efficacy of the experimental group was better than the control group.2.Symptom points Before treatment: There was no significant difference between the two groups(P>0.05).After treatment,the total score of the two groups was lower than that before treatment(P<0.05).The total score of syndrome in the experimental group was lower than that in the control group(P<0.05).Compared with the single symptom,(P<0.05).There was no significant difference in the remaining symptom scores(P>0.05),but there was no significant difference between the two groups(P>0.05).3.Pathology score There was no significant difference in the total score of pathological indexes between the two groups before treatment(P>0.05).After treatment,the total score of the two groups of pathology were lower than before treatment(P<0.05).The total score of pathologic indicators in the experimental group was lower than that in the control group(P<0.05)4.Pathological efficacy(1)chronic inflammation: the experimental group was cured in 10 cases,markedly effective in9 cases,effective in 10 cases,6 cases,the total effective rate of 82.86%;the control group of clinical cure in 4 cases,markedly effective in 8 cases,effective in 9 cases,The total effective rate of 60%.(2)Inflammatory activity: The clinical group was cured in 8 cases,markedly effective in 11 cases,effective in 13 cases,ineffective in 3 cases,the total effective rate was 91.43%;the control group was cured in 4 cases,markedly effective in 7 cases,effective in 14 cases,the total efficiency of 71.43%.(3)atrophy: the clinical group cured 4cases,markedly effective in 10 cases,effective in 13 cases,8 cases,the total effective rate of 77.14%;the control group1 case of clinical cure,markedly effective in 9 cases,effective in 9 cases,Effective rate of 54.29%.(4)Intestine: 21 cases of experimental group participated in the statistics,clinical cure in 1 case,markedly effective in 8 cases,effective in 6cases,ineffective in 6 cases,the total effective rate was71.43%;control group of 20 cases of statistics,markedly 4 cases,effective in 6 cases,10 cases,the total effective rate of50.00%.There was significant difference between the two groups(P<0.05),which indicated that the curative effect of the first three pathological indexes was better than that of the control group,and the effect of the two groups was similar.5.Comprehensive effect The experimental group: clinical recovery in 4 cases,markedly effective in 14 cases,effective in 12 cases,5 cases,the total effective rate of 85.71%;control group: markedly effective in 9 cases,effective in 13 cases,ineffective in 13 cases,the total effective rate of 62.86%.There was significant difference between the two groups(P<0.05),indicating that the efficacy of the experimental group was better than the control group.6.Long-term efficacy The recurrence rate was 8.57% in the experimental group and 28.57% in the control group.There was significant difference between the two groups(P<0.05),which indicated that the control group was better than the control group.Conclusion:He Wei Yu Wei decoction treating Liver-Stomach Heat type chronic atrophic gastritis can achieve better efficacy,with good safety,low recurrence rate.This can greatly alleviate the symptoms of patients,improve endoscopy and biopsy results,reduce the recurrence rate,improve the quality of life.In summary,the stomach and more treatment of liver and stomach Yu treatment of CAG does have a curative effect,should be further research and promotion in clinical. |
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