| 1 Objective To compare the effect of cellular immune function in maintenance hemodialysis patients(MHD)with different blood purification modality,and also observe the influence of above factors on the decline of hepatitis B surface antibody titer.In order to provide theoretical support for deciding on the best method of blood purification modality that effectively prevent hepatitis B virus(HBV)infection and improve the quality of their survival.2 Methods Sixty six MHD patients were randoml divided into three groups that respectively received treatment of hemodialysis(HD),hemodialysis+hemoperfusion(HD+HP),hemodiafiltration(HDF),twenty two in each group.Peripheral blood T lymphocyte subsets(CD3+,CD4+,CD8+,CD4+/CD8+ ratio)and anti-HBs titer levels were detected before dialysis and 6 months after dialysis in all cases.3 Results Compared with that before treatment,CD3+,CD4+ in HD+HP and HDF groups increased obviously(P<0.05),CD8+,CD4+/CD8+ ratio without statistical significance in the two groups(P>0.05),while without statistical significance in each indicators was observed in HD group(P>0.05).The anti-HBs titer were all decreased before treatment in each group,but the HD group decreased rapidly with statistical significance(p<0.05),the HD+HP and HDF groups decreased relatively slow without statistical significance(P>0.05).After the treatment,compared with the HD group,CD3+,CD4+ in HD+HP and HDF groups are increased(P<0.05),the anti-HBs titer decreased relatively slow with statistical significance(P<0.05),while CD8+,CD4+/CD8+ ratio without statistical significance(P > 0.05).Compared with HD+HP group,CD3+,CD4+,CD8+,CD4+/CD8+ ratio,anti-HBs titer in HDF group without statistical significance(P>0.05).4 Conclusion T lymphocyte subgroup imbalances and cellular immune dysfunction exists in MHD patients,HD+HP and HDF can briefly improve the cellular immune function of MHD patients,delay the anti-HBs titer attenuation.There is no difference between the treatment effect in HD+HP and HDF. |
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