Effects Of Different Doses Dexmedetomidine On Prevention Of Dysphoria In Children's Recovery Period

Objective:To observe the effect of different doses of dexmedetomidine on the incidence of dysphoria and guide the anesthesia regimen.Methods:Sixty children who received tonsillectomy and adenoidectomy at the same time under general anesthesia were randomly divided into three groups: pumped dexmedetomidine 1.0 ug / kg group (A group) , pumped dexmedetomidine 0.5ug / kg group (B group),pumped saline group (C group).Monitor and record the HR, MBP, SPO2 and ETCO2 changes when the children went into the PACU (T1) , before extubation (T2) , extubation (T3) , after extubation 5 minutes (T4) . Observe and record three groups of children wake up time, stay time in PACU, and the occurrence of adverse events. Record the Ramsay sedation score 1 to 4 hours after extubation. The differences between groups were compared, and the data were analyzed statistically.Results:There were no significant differences in the general data of each group.(1) The incidence of dysphoria was significantly higher in children with C group than in the other two groups. The incidence rates of postoperative dyphoria in A group, B group, and C group were 10%, 30% and 80%, there was statistically significant difference among the three groups (P<0.05 );(2) The hemodynamics of group A and group B were more stable than those of group C after extubation, and the statistical analysis was statistically significant (P<0.05);(3) Compared with group C, 1-4-hour Ramsay score in A group and B group increased significantly (P <0.05);Conclusion:The use of dexmedetomidine in general anesthesia can effectively reduce the incidence of dysphoria in pediatric tonsillectomy and adenoidectomy. Hemodynamics were more stable during extubation, 4 hours of postoperative quiet sleep rate is high,the incidence of adverse events is low, and pumped dexmedetomidine 1.0 ug · kg is better.