Studies On Chemical Constituents Of The Roots Of Morinda Officinalis How.

Morinda officinalis How.belongs to the genus Morinda.The roots of M.officinalis have been reported to possess the ability to reinforce kidney function,strengthen the tendons and bones,and relieve rheumatic condition.A lot of researches have shown that M.officinalis has anti-inflammatory,anti-fatigue,anti-aging,antioxidant and antiviral activities.26 compounds were isolated from the roots of M.officinalis by silica gel,Sephadex LH-20 and polyamide column chromatography together with recrystallization purification.24 compounds of them were identified as 2,5,8-trihydroxy-1-methoxyanthraquinone(MOE-4),1-methoxy-2-hydroxy anthraquinone(MOP-3),lucidin-?-ethyl ether(MOP-4),sitosterol(MOP-5),1,4-dihydroxyanthraquinone(MOP-6),1-hydroxy-2-methylanthraquinone(MOP-7),2-methylanthraquinone(MOP-8),morindaparvin-A(MOP-9),daucosterol(MOE-1),rubiadin(MOE-2),rubiadin-1-methylether(MOE-3),3-hydroxy-2-hydroxymethylanthraquinone(MOE-6),1,2-dimethoxy-3-hydroxyanthraquinone(MOE-9),1,3-dimethoxy-2-hydroxyanthraquinone(MOE-11),glucose(MOE-13),monotropein(MOE-14),n-butyl-O-?-D-fructopyranoside(MOB 30-1),2-O-butyl-?-D-fructofuranoside(MOB 30-2),2-O-butyl-?-D-fructofuranoside(MOB 30-3),ningpogenin(MOB 30-4),sucrose(MOB 30-6),monotropein-1-methylether(MOB 30-7),inulin hexasaccharide(MOH 30-1),kestose(MOH 30-2).The compounds were identified by the extensive use of 1D and 2D NMR experiments,together with IR,UV and HRESIMS spectra.Among the 24 compounds,MOE-4 was a new compound,and MOP-6,MOE-11,MOB 30-3,and MOB 30-7 were reported from the genus Morinda for the first time.Otherwise,a review of studies on chemical constituents of the genus Morinda had been made in the thesis.As reported,anthraquinones,iridoids and saccharides were main components in the genus Morinda.