The Clinical Observation Of Guanxin Decoction Treat Re-sidual Lesion Angina Pectoris After Percutaneous Coro-Nary Intervention With Qi Deficiency And Blood Stasis Syndrome

Object:To observe the curative efficacy and safety of Guanxin Decoction in the treatment of Residual Lesion Angina Pectoris after Percutaneous Coronary Intervention with Qi Deficien-cy and Blood Stasis Syndrome,to discuss its mechanism of action preliminarily,to offer reli-able evidences on clinical use of Guanxin decoction,to offer new ideas on the treatment of this disease.Methods:There are 60 patients were hospitalized in XuZhou hospital of traditional Chinese medicine diagnosed from April 2016 to January 2017 with Residual Lesion Angina Pectoris after Percutaneous Coronary Intervention with Qi Deficiency and Blood Stasis Syndrome.They were randomly segmented into two groups.There were 33 patients in the Guanxin De-coction group,while there were 27 patients in the control group.Patients in the control group preclude the use of conventional western medicine(such as aspirin,metoprolol,clopidogrel,atorvastatin calcium,etc.).The Guanxin Decoction group was added Guanxin Decoction more.1 month for 1 course of treatment,observed 3 periods of treatment.When the observa-tion is over,compared the changes of the classification of angina pectoris,The Seattle Angina Questionnaire(SAQ,Appendix 1),TCM syndrome points(Appendix 2),Integral quality of life(SF-36,Appendix 3),total cholesterol(TC),high sensitivity C reactive protein(hs-CRP),low density lipoprotein(LDL),high density lipoprotein(HDL)and the safety indicators of two groups before and after treatment in both groups.SPSS 20.0 statistical software was used to analyze the above indicators.Results:After treatment,the two groups were significantly improved in SAQ,TCM syn-drome integral scores and SF-36,while that of the Guanxin Decoction group improved more significantly than the other group(P<0.05).The general effective percentage of Guanxin Decoction group is significantly higher than the other’s(P<0.05).The improvement of the classification of angina pectoris was more significant in the Guanxin Decoction group(P<0.05),while there was no significant improvement in the classification of angina pectoris in the control group(P>0.05).After treatment,TC,hs-CRP and LDL were evidently decreased in the both groups.The Guanxin Decoction group was dramatically lower than the control group in hs-CRP,TC and LDL.The difference between the two groups were statistically definite(P<0.05).After therapy,HDL values in the two groups were observably increased in the two groups.There was no evident difference between the two groups(P>0.05).Conclusion:Guanxin Decoction combined with western medicine therapy can significantly improve patients who with Residual Lesion Angina Pectoris after Percutaneous Coronary In-tervention with Qi Deficiency and Blood Stasis Syndrome.They can reduce the recurrence rate of angina pectoris and the inflammation,improve lipid metabolism,and they have rela-tively good clinical security.Therefore,it is worthy of popularization and use.