Studies On Anti-gout And Anti-hyperuricemia Activity Of The Extract Of Sunflower(Helianthus Annuus Linn) Disc

Sunflower(Helianthus annuus L.)is widely cultivated in China,as an important oil crop,sunflower in the food industry has a very important application.As a by-product resource of the sunflower,disk,straw,seed shell,etc.,also used as an important industrial raw materials.Sunflower body can be medicine,and sunflower disk in the civil prescription,was used to treat asthma,dysmenorrhea and other diseases,the effect is significant.Modern pharmacological studies have also confirmed that sunflower disk with anti-tumor,antihypertensive,anti-oxidation and other pharmacological effects,we studied its anti-gout and anti-hyperuricemia activity.Gout is due to purine metabolic disorders,resulting in abnormal uric acid content caused by metabolic diseases.The incidence of uric acid excretion or uric acid excess production.According to the course of disease is divided into acute onset and chronic onset.Acute treatment of the treatment of drugs to reduce inflammation,relieve pain as the main purpose.Chronic episodes of drugs to control blood uric acid content as the main purpose.However,the existing treatment of gout and hyperuricemia drugs,mostly chemicals,with more toxic side effects,so more and more researchers are committed to finding alternatives from natural plants.In this study,sunflower extract(SDE)extracted from 0%,20%,40%,60%,80% and 100% ethanol was used to induce acute gouty arthritis in rats by injecting sodium uranate(MSU)Swelling and anti-inflammatory activity of right knee in rats with arthritis.The results showed that SDE could significantly inhibit the swelling,with 20% SDE inhibited the best,making the swelling decreased by 27.1%(P<0.05).Moreover,SDE can significantly increase the serum IL-10 and MIP-1? content,play an inhibitory effect on inflammation,and thus from the source of inflammatory treatment of acute gouty arthritis.At the same time,the content of inflammatory factors in plasma of gout was analyzed by proteome.The results showed that SDE significantly increased the content of IL-10.In this paper,mouse hyperuricemia model was induced by injection of potassium oxonate(OXO),and test the effect of SDE on SUA,XO activity and oxidative stress-related factors.The results showed that SDE could decrease the uric acid content of hyperuricemia mice,and the effect of 20% SDE was the most significant,which was 49.96%(P<0.01).Furthermore,SDE was able to inhibit XO activity and thereby reduce uric acid production.In addition,SDE inhibited SOD,GSH-Px activity,decreased MDA,NO content,reduce oxidative damage.SDE has a promising prospect in the treatment and prevention of gout because of its significant anti-gouty arthritis and antihypertensive activity.