Anti-Gouty Arthritis And Anti-hyperuricemia Properties Of Celery Seed Extracts

Celery(Apium graveolens L)is a herb mainly used as an edible vegetable.However,its medicinal value has also been used by people.Celery has a health-care effect on the stomach and promotes the functioning of the brain.It also has the effect of relieving nerves.In addition,apigenin in celery has the effects of resisting oxidative stress damage,relieving inflammation,lowering blood pressure and blood fat.According to pharmacological studies,celery extract also has analgesic and anti-tumor effects,and celery seed extract has anti-oxidation effect.Although there has been some research on the use of celery seeds in medical applications,its anti-oxidation and antiinflammatory effects have not been completely studied,and the role of anti-gout characteristics has not been fully reported yet.According to the different stages of gout,it can be classified into hyperuricemia stage and acute gouty arthritis stage.Hyperuricemia is a metabolic disease,the main reason for hyperuricemia is that the system of purine metabolic in the human body is disordered,resulting in an increase in the amount of uric acid synthesis or a decrease in uric acid excretion in the body.When the uric acid level exceeds its maximum solubility in the body,uric acid deposits in the form of urate in the joint and its surrounding tissues,leading to the occurrence of acute gouty arthritis.At present,the drugs for the treatment of these two diseases are mainly chemical drugs,and the chemical drugs are limited in their therapeutic applications due to their toxic side effects.Therefore,more and more researchers are working to find natural drugs with small side effects instead of chemical drugs.In our study,we administered yeast powder and potassium oxonate(OXO)by intragastric and intraperitoneal injection,respectively,to induce and breed mice with hyperuricemia,to evaluate the effect of celery seed aqueous extract(CSAE)and celery seed supercriticality carbon dioxide fluid extraction oil(CSOL)on blood uric acid(SUA),xanthine oxidase(XO)activity and oxidative stress related factors.The results showed that CSAE and CSOL not only reduced the level of SUA,but also inhibited the activity of XO and decreased the levels of reactive oxygen species(ROS),and increased serum superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px).In this study,a rat model of acute gouty arthritis was induced by injection of sodium urate(MSU)to evaluate the effect of CSAE and CSOL on the reduction of swelling degree and anti-inflammatory activity of the right ankle joint of the model rats.The results showed that CSAE and CSOL reduced the swelling of the right ankle joint,also reduced the inflammatory cell infiltration around the ankle joint and reduced the levels of serum interleukin-1?(IL-1?)and tumor necrosis factor alpha(TNF-?)in rats and increase the level of interleukin 10(IL-10).In this study,we successfully confirmed that celery seed extract shows its antiinflammatory and anti-oxidant properties,which may be at least partially related to their modulation on oxidative stress and inflammation response.